CAJ | 학술논문

随着碳青霉烯类药物的使用，耐碳青霉烯类铜绿假单胞菌逐渐增多，在世界各地医院暴发流行，已成为一个威胁人类健康的严重公共卫生问题。耐碳青霉烯类铜绿假单胞菌的主要耐药机制有外膜通透性降低（ OprD2突变或丢失）、主动外排机制及金属碳青霉烯酶水解作用。目前对耐碳青霉烯类铜绿假单胞菌有效的抗菌药物非常有限，深入了解耐碳青霉烯类铜绿假单胞菌的耐药机制，对开展新药研究及临床合理使用抗菌药物具有一定的意义。
수착탄청매희류약물적사용，내탄청매희류동록가단포균축점증다，재세계각지의원폭발류행，이성위일개위협인류건강적엄중공공위생문제。내탄청매희류동록가단포균적주요내약궤제유외막통투성강저（ OprD2돌변혹주실）、주동외배궤제급금속탄청매희매수해작용。목전대내탄청매희류동록가단포균유효적항균약물비상유한，심입료해내탄청매희류동록가단포균적내약궤제，대개전신약연구급림상합리사용항균약물구유일정적의의。
The outbreaks and the increased prevalence of carbapenem -resistant Pseudomonas aeruginosa have been continuously reported in hos-pitals worldwide , along with the increasing usage of Carbapenems .The infection caused by CRPA poses a serious public health threat . The mainly mechanisms of Pseudomonas aeruginosa resistant to carbapenems are the decreasing expression of outer membrane protein ( the mutation or loss of OprD 2 ) , the over-expression of efflux pump system , and the ca-pability of metallo-β-lactamases to hydrolyze most carbapenems , and so on.The effective antibiotics against carbapenem -resistant Pseudo-monas aeruginosa are limited.The insights into mechanisms of Pseudo-monas aeruginosa resistant to carbapenems may contribute to the develop-ment of new drugs and rational application of antibiotics in clinic .