海峡药学
海峽藥學
해협약학
STRAIT PHARMACEUTICAL JOURNAL
2015年
4期
18-20
,共3页
细叶远志皂苷%在体单向肠灌流%重量法%吸收部位
細葉遠誌皂苷%在體單嚮腸灌流%重量法%吸收部位
세협원지조감%재체단향장관류%중량법%흡수부위
Tenuifolin%In situ single pass perfusion model%Gravimetry%Absorption site
目的：研究细叶远志皂苷在大鼠四个肠段的吸收状况。方法运用大鼠在体单向肠灌流模型，采用重量法，研究细叶远志皂苷在不同肠段的吸收情况。结果在体小肠吸收实验中，细叶远志皂苷可被大鼠全肠段吸收，在十二指肠、空肠、回肠及结肠各肠段的药物吸收速率常数（Ka）分别是0．05922，0．06387，0．06345，0．06409s－1；药物表观吸收系数（Papp）分别是0．03322，0．03751，0．03733，0．04830cm? s－1，结肠段吸收最好（P＜0．001）。结论细叶远志皂苷为全肠道吸收的药物，且结肠部位吸收最好。
目的：研究細葉遠誌皂苷在大鼠四箇腸段的吸收狀況。方法運用大鼠在體單嚮腸灌流模型，採用重量法，研究細葉遠誌皂苷在不同腸段的吸收情況。結果在體小腸吸收實驗中，細葉遠誌皂苷可被大鼠全腸段吸收，在十二指腸、空腸、迴腸及結腸各腸段的藥物吸收速率常數（Ka）分彆是0．05922，0．06387，0．06345，0．06409s－1；藥物錶觀吸收繫數（Papp）分彆是0．03322，0．03751，0．03733，0．04830cm? s－1，結腸段吸收最好（P＜0．001）。結論細葉遠誌皂苷為全腸道吸收的藥物，且結腸部位吸收最好。
목적：연구세협원지조감재대서사개장단적흡수상황。방법운용대서재체단향장관류모형，채용중량법，연구세협원지조감재불동장단적흡수정황。결과재체소장흡수실험중，세협원지조감가피대서전장단흡수，재십이지장、공장、회장급결장각장단적약물흡수속솔상수（Ka）분별시0．05922，0．06387，0．06345，0．06409s－1；약물표관흡수계수（Papp）분별시0．03322，0．03751，0．03733，0．04830cm? s－1，결장단흡수최호（P＜0．001）。결론세협원지조감위전장도흡수적약물，차결장부위흡수최호。
ABSTRACT:OBJECTIVE To study the absorption condition of tenuifolin in four intestine Segments in rats.METHODS In situ single pass perfusion model of rat was set up,taking gravimetry as a marker,the absorption of tenuifolin in small intestine was studied.RESULTS The tenuifolin could be absorbed in whole intestinal seg-ments.The absorption rate constants ( Ka ) of tenuifolin at duodenum, jejunum, ileum and colon was 0.05922, 0.06387,0.06345,0.06409s-1,respectively;the apparent permeability coefficients (Papp) was 0.03322,0.03751, 0.03733 ,0.04830 cm? s-1 .Ka and Papp at colon were significantly higher than that at the other regions of intestine (P<0.001).CONCLUSION Tenuifolin can be absorbed in the whole intes-tinal,especially in colon.
