CAJ | 학술논문

[目的]用三维动脉自旋标记(three dimensioned arterial spin labelling,3D－ASL)对正常老年人主要脑功能区进行MR灌注成像，探索其局部血流灌注范围，为老年人脑功能区血流灌注研究提供参考。[方法]对32例正常志愿老年人（年龄60～68岁）进行MRI常规扫描和3D－ASL灌注扫描，获得血流量图，分别测得双侧初级躯体运动区、初级躯体感觉区、听觉区、视觉区、运动性语言中枢、听觉性语言中枢、视觉性语言中枢、书写性语言中枢的脑血流灌注量(cerebral blood flow，CBF)，进行统计分析。[结果]颅脑各部位血流灌注量[单位：mL/(min·100 g)]分别为：初级躯体运动区59．22±12．72、初级躯体感觉区62．28±14．97、视觉区66．75±13．54、听觉区53．64±12．71、运动性语言中枢66．64±12．65、听觉性语言中枢54．56±11．32、视觉性语言中枢58．37±13．24、书写性语言中枢61．64±12．71。男性与女性的血流量未见明显差异（P>0．05）。[结论]3D－ASL灌注成像能定量测量老年人脑功能区血流量；作为一种无创的血流动力学检查新技术，3D－ASL对脑血流灌注的研究有着较高的应用价值。
[목적]용삼유동맥자선표기(three dimensioned arterial spin labelling,3D－ASL)대정상노년인주요뇌공능구진행MR관주성상，탐색기국부혈류관주범위，위노년인뇌공능구혈류관주연구제공삼고。[방법]대32례정상지원노년인（년령60～68세）진행MRI상규소묘화3D－ASL관주소묘，획득혈류량도，분별측득쌍측초급구체운동구、초급구체감각구、은각구、시각구、운동성어언중추、은각성어언중추、시각성어언중추、서사성어언중추적뇌혈류관주량(cerebral blood flow，CBF)，진행통계분석。[결과]로뇌각부위혈류관주량[단위：mL/(min·100 g)]분별위：초급구체운동구59．22±12．72、초급구체감각구62．28±14．97、시각구66．75±13．54、은각구53．64±12．71、운동성어언중추66．64±12．65、은각성어언중추54．56±11．32、시각성어언중추58．37±13．24、서사성어언중추61．64±12．71。남성여녀성적혈류량미견명현차이（P>0．05）。[결론]3D－ASL관주성상능정량측량노년인뇌공능구혈류량；작위일충무창적혈류동역학검사신기술，3D－ASL대뇌혈류관주적연구유착교고적응용개치。
Objective]To explore the perfusion characteristics of the aged cerebral functional areas by magnetic resonance(MR) three dimension arterial spin labeling(3D-ASL). [Methods]32 aged volunteers(age range, 60~68) were examined for cerebral MR perfusion from February 2013 to July 2014 with 3D-ASL. The parameter maps of cerebral blood flow(CBF) were created by the perfusion software. The mean CBF of different functional regions were measured and statistically analyzed.[Results]The mean CBF[unit, mL/(min·100g)] of the primary motor area, primary somatic area, auditory area, visual area, motor speech area, auditory speech area, visual speech area, writing area were 59.22±12.72, 62.28±14.97, 66.75±13.54, 53.64±12.71, 66.6±12.65, 54.5±11.32, 58.37±13.24, 61.64±12.71, respectively. There were statistical differences in the different cerebral functional areas,but not between genders. [Conclusion]This study indicates 3D-ASL could provide useful perfusion information. Because of its noninvasiveness,3D-ASL may be an appealing approach for further studies of cerebral function imaging.