CAJ | 학술논문

目的：讨论唑来膦酸联合化疗治疗多发性骨髓瘤骨病的疗效。方法：60例患有多发性骨髓瘤的患者，按照不同的治疗方案随机分为化疗组30例，即单用VAD（长春新碱+阿霉素+地塞米松）方案治疗组；联合组30例，即唑来膦酸联合VAD方案治疗组。2个疗程后观察两组患者骨痛缓解程度，评价其疗效并用骨ECT了解病灶状况。结果：联合组30例患者经过治疗后得到了不同程度的效果，其中显效的10例，有效的16例，无效的4例，有效率为86.7%。化疗组20例患者治疗后，其中显效的6例，有效的14例，无效的10例，有效率66.7%。两组疗效差异显著，具有统计学意义（P＜0.05）。联合组15例患者影像学检查报告显示病灶区骨质破坏程度降低并有新骨的形成，联合治疗组中血钙浓度较治疗前有所下降，无高血钙症。结论：唑来膦酸联合化疗治疗多发性骨髓瘤骨病的疗效确切，不良反应少，值得临床应用。
목적：토론서래련산연합화료치료다발성골수류골병적료효。방법：60례환유다발성골수류적환자，안조불동적치료방안수궤분위화료조30례，즉단용VAD（장춘신감+아매소+지새미송）방안치료조；연합조30례，즉서래련산연합VAD방안치료조。2개료정후관찰량조환자골통완해정도，평개기료효병용골ECT료해병조상황。결과：연합조30례환자경과치료후득도료불동정도적효과，기중현효적10례，유효적16례，무효적4례，유효솔위86.7%。화료조20례환자치료후，기중현효적6례，유효적14례，무효적10례，유효솔66.7%。량조료효차이현저，구유통계학의의（P＜0.05）。연합조15례환자영상학검사보고현시병조구골질파배정도강저병유신골적형성，연합치료조중혈개농도교치료전유소하강，무고혈개증。결론：서래련산연합화료치료다발성골수류골병적료효학절，불량반응소，치득림상응용。
Objective To discuss azole phosphonic acid chemotherapy curative effect for the treatment of multiple myeloma bone disease.Methods 60 cases of patients with multiple myeloma, according to the different chemotherapy were randomly divided into treatment group 30 cases; Joint group 30 cases. After 2 courses of observing two groups of patients with bone pain remission, ECT, evaluate its efficacy and bone lesions.Results Joint group of patients after treatment by different degrees of effects, one of the 10 cases were markedly improved, effective in 16 cases, 4 cases were invalid, the effective rate was 86.7%. Chemotherapy group 20 patients after treatment, including the 6 cases were markedly effective, effective 14 cases, 10 cases were invalid, the effective rate was 66.7%. Significant difference was found in two groups of curative effect, with statistical significance (P < 0.05).Conclusions Azole to phosphonic acid combined with chemotherapy in the treatment of multiple myeloma bone disease curative effect, less adverse reactions, worthy of clinical application.