CAJ | 학술논문

[目的]探索磁共振动脉自旋标记( aterial spin labeling，ASL)技术在缺血性脑卒中患者功能恢复评价中的应用价值。[方法]对经临床及影像学证实的40例缺血性脑卒中患者采用1．5T超导MR进行ASL扫描检查，将原始图像进行处理后获得梗死区域脑血流量(cerebral blood flow，CBF)，取同层面对侧正常脑白质区灌注值作为对照，求其比值，从而得出平均相对脑血流量(relative cerebral blood flow，rCBF)。分别对治疗前所得rCBF与功能独立性评定(function independent measure,FIM)评分、治疗前后所得rCBF与FIM评分变化进行相关性分析。[结果]治疗前后所得梗死区域rCBF差异、FIM评分差异均有统计学意义(P<0．05)；治疗前所得rCBF与FIM评分显著正相关( r=0．91)，rCBF的变化与FIM的评分变化显著正相关( r=0．80)。[结论]作为一种无创性的MR灌注方法，ASL技术可考虑作为常规检查方法来评估临床治疗缺血性脑卒中的疗效，从而指导治疗方法的应用和调整。
[목적]탐색자공진동맥자선표기( aterial spin labeling，ASL)기술재결혈성뇌졸중환자공능회복평개중적응용개치。[방법]대경림상급영상학증실적40례결혈성뇌졸중환자채용1．5T초도MR진행ASL소묘검사，장원시도상진행처리후획득경사구역뇌혈류량(cerebral blood flow，CBF)，취동층면대측정상뇌백질구관주치작위대조，구기비치，종이득출평균상대뇌혈류량(relative cerebral blood flow，rCBF)。분별대치료전소득rCBF여공능독립성평정(function independent measure,FIM)평분、치료전후소득rCBF여FIM평분변화진행상관성분석。[결과]치료전후소득경사구역rCBF차이、FIM평분차이균유통계학의의(P<0．05)；치료전소득rCBF여FIM평분현저정상관( r=0．91)，rCBF적변화여FIM적평분변화현저정상관( r=0．80)。[결론]작위일충무창성적MR관주방법，ASL기술가고필작위상규검사방법래평고림상치료결혈성뇌졸중적료효，종이지도치료방법적응용화조정。
Objective] To explore the potential clinical application of arterial spin labeling(ASL) technique in the evaluation of curative effect by comparing the perfusion index and the activities of daily living before and after the treatment in combination of traditional Chinese and western medicines for the ischemic stroke. [Methods] 40 cases of ischemic stroke were confirmed by the clinical and imaging performed ASL scan with the 1.5 T superconducting MR, the original image was processed to obtain rCBF in infarction area. Linear Regression analysis was performed to detect the correlation between the rCBF obtained by ASL and FIM before treatment, changes of rCBF and FIM before and after treatment.[Results]The changes of rCBF and FIM before and after treatment had statistically significant difference(P<0.05). The rCBF and FIM before treatment, changes of rCBF and FIM before and after treatment had significant positive correlation, correlation coefficient r=0.91, r=0.80.[Conclusion] As a non-invasive MR perfusion method,ASL can be considered as a routine method to evaluate clinical efficacy of the treatment for ischemic stroke, guiding the application and adjustment of treatment.