CAJ | 학술논문

精子活动力是衡量男性生育能力的一个重要指标，只有活动的精子才能到达受精部位。精子活力低下症是男性不育的主要因素，严重危害人类的生殖健康。随着自由基等分子生物学理论的建立和发展，人们发现氧化应激信号通路对精子的损伤可能是男性不育的原因之一。蛋白激酶 C（PKC）、细胞外调节蛋白激酶（ERK）信号通路的研究对基于分子水平探讨精子活力低下症的发病机制，寻求其治疗新途径和方法具有重要意义。
정자활동력시형량남성생육능력적일개중요지표，지유활동적정자재능도체수정부위。정자활력저하증시남성불육적주요인소，엄중위해인류적생식건강。수착자유기등분자생물학이론적건립화발전，인문발현양화응격신호통로대정자적손상가능시남성불육적원인지일。단백격매 C（PKC）、세포외조절단백격매（ERK）신호통로적연구대기우분자수평탐토정자활력저하증적발병궤제，심구기치료신도경화방법구유중요의의。
The sperm motility is an important indicator of male inferitility.Obviously,asthenospermia is not good for the human reproduction as it’s a key factor of male infertility.However,with the development of the mo-lecular biology,such as free radical,we come to find that the damage of the oxidative stress pathway may lead to male infertility.Therefore,it is of great importance to study the signal pathway of PKC and ERK so that we can dis-cuss the cause of male infertility on molecular level and find a new way to solve this problem.