中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2015年
4期
112-114
,共3页
多囊卵巢综合征%来曲唑%阿司匹林%排卵障碍
多囊卵巢綜閤徵%來麯唑%阿司匹林%排卵障礙
다낭란소종합정%래곡서%아사필림%배란장애
Polycystic ovarian syndrome (PCOS)%Letrozole%Aspirin%Ovulation failure
目的:探析来曲唑和阿司匹林联合治疗对多囊卵巢综合征(PCOS)导致排卵障碍患者的有效性和安全性。方法:入选我院2012年6月至2013年6月收治的 PCOS 导致排卵障碍患者100例,根据入院先后顺序分为两组各50例,观察组采用来曲唑和阿司匹林联合治疗,对照组采用克罗米芬治疗,比较两组临床疗效及安全性。结果:观察组治疗有效率94.0%(47/50)显著高于对照组80.0%(40/50),血清 E2、FSH、T 和 LH 水平显著低于对照组,排卵率94.0%(47/50)显著高于对照组78.0%(39/50),妊娠率80.0%(40/50)显著高于对照组36.0%(18/50),流产率20.0%(10/50)显著低于对照组64.0%(32/50),差异均具有统计学意义(均 P <0.05),且两组均未见明显不良反应。结论:来曲唑和阿司匹林联合治疗 PCOS 所致排卵障碍疗效显著,有效改善性激素水平,提高排卵率和妊娠率,且安全性好。
目的:探析來麯唑和阿司匹林聯閤治療對多囊卵巢綜閤徵(PCOS)導緻排卵障礙患者的有效性和安全性。方法:入選我院2012年6月至2013年6月收治的 PCOS 導緻排卵障礙患者100例,根據入院先後順序分為兩組各50例,觀察組採用來麯唑和阿司匹林聯閤治療,對照組採用剋囉米芬治療,比較兩組臨床療效及安全性。結果:觀察組治療有效率94.0%(47/50)顯著高于對照組80.0%(40/50),血清 E2、FSH、T 和 LH 水平顯著低于對照組,排卵率94.0%(47/50)顯著高于對照組78.0%(39/50),妊娠率80.0%(40/50)顯著高于對照組36.0%(18/50),流產率20.0%(10/50)顯著低于對照組64.0%(32/50),差異均具有統計學意義(均 P <0.05),且兩組均未見明顯不良反應。結論:來麯唑和阿司匹林聯閤治療 PCOS 所緻排卵障礙療效顯著,有效改善性激素水平,提高排卵率和妊娠率,且安全性好。
목적:탐석래곡서화아사필림연합치료대다낭란소종합정(PCOS)도치배란장애환자적유효성화안전성。방법:입선아원2012년6월지2013년6월수치적 PCOS 도치배란장애환자100례,근거입원선후순서분위량조각50례,관찰조채용래곡서화아사필림연합치료,대조조채용극라미분치료,비교량조림상료효급안전성。결과:관찰조치료유효솔94.0%(47/50)현저고우대조조80.0%(40/50),혈청 E2、FSH、T 화 LH 수평현저저우대조조,배란솔94.0%(47/50)현저고우대조조78.0%(39/50),임신솔80.0%(40/50)현저고우대조조36.0%(18/50),유산솔20.0%(10/50)현저저우대조조64.0%(32/50),차이균구유통계학의의(균 P <0.05),차량조균미견명현불량반응。결론:래곡서화아사필림연합치료 PCOS 소치배란장애료효현저,유효개선성격소수평,제고배란솔화임신솔,차안전성호。
Objectives:To discuss and analyze the effectiveness and safety of letrozole combined aspirin for treatment of ovulation failure caused by polycystic ovarian syndrome (PCOS).Method:100 patients with ovulation failure caused by PCOS during June 2012 to June 2013 were chosen and according to admission order divided into 2 groups,each with 50 cases.Observation group was treated with letrozole combined aspirin while control group was treated with clomiphene.Clinical effect and safety of the 2 groups were compared.Result:The effective rate of ob-servation group was 94.0% (47 /50),obviously higher than control group of 80.0% (40 /50).The serum E2 , FSH,T and LH level were obviously lower than control group;ovulation rate was 94.0% (47 /50)obviously higher than control group of 78.0% (39 /50);pregnancy rate was 80.0% (40 /50)was obviously higher than control group of 36.0% (18 /50);and abortion rate was 2.0% (1 /50)obviously lower than control group of 16.0% (8 /50)(all P <0.05).There were no obvious adverse reactions in the 2 groups.Conclusion:Letrozole combined aspirin has an obvious clinical effect for treatment of ovulation failure caused by PCOS.It can improve sex hormone level,ovu-lation rate and pregnancy rate,with good safety.