CAJ | 학술논문

目的：评价红霉素、阿奇霉素序贯疗法与单用阿奇霉素治疗小儿肺炎支原体肺炎的临床疗效。方法入选114例小儿肺炎支原体肺炎，并随机分为2组，每组57例。试验组用红霉素25～30 mg? kg -1每天1次滴注，3～7 d后改口服阿奇霉素10 mg? kg-1，3 d后停药4 d。对照组口服阿奇霉素10 mg? kg-1每天1次，5 d后停药7 d，再口服阿奇霉素10 mg? kg-1，每天1次，3 d后停药4 d。2组均3周为1个疗程，比较2组患儿的临床疗效、临床症状消失时间、住院时间及不良反应发生率。结果治疗后，试验组的总有效率为96.49％，显著高于对照组的77.19％（ P＜0.01）；试验组退热时间、止咳时间、湿啰音消失时间及住院时间均明显低于对照组（ P＜0.01）；观察组的不良反应发生率为7.02％，对照组为3.51％，差异无统计学意义（ P＞0.05）。结论红霉素、阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的疗效显著。
목적：평개홍매소、아기매소서관요법여단용아기매소치료소인폐염지원체폐염적림상료효。방법입선114례소인폐염지원체폐염，병수궤분위2조，매조57례。시험조용홍매소25～30 mg? kg -1매천1차적주，3～7 d후개구복아기매소10 mg? kg-1，3 d후정약4 d。대조조구복아기매소10 mg? kg-1매천1차，5 d후정약7 d，재구복아기매소10 mg? kg-1，매천1차，3 d후정약4 d。2조균3주위1개료정，비교2조환인적림상료효、림상증상소실시간、주원시간급불량반응발생솔。결과치료후，시험조적총유효솔위96.49％，현저고우대조조적77.19％（ P＜0.01）；시험조퇴열시간、지해시간、습라음소실시간급주원시간균명현저우대조조（ P＜0.01）；관찰조적불량반응발생솔위7.02％，대조조위3.51％，차이무통계학의의（ P＞0.05）。결론홍매소、아기매소서관요법치료소인폐염지원체폐염적료효현저。
Objective To evaluate the clinical efficacy of erythromycin and azithromycin sequential therapy with single azithromycin treatment on pediatric mycoplasma pneumonia .Methods One hundred and fourteen cases of pediatric mycoplasma pneumonia were randomly divided into two groups, with 57 cases in each group.Patients in the treatment group were treated with erythromycin combined with azithromycin , and those in the control group were treated with azithromycin , and the treatment lasted for 3 weeks.The data of clinical efficacy , clinical symptoms and hospitaliza-tion time of two groups were compared after treatment . Results The total effective rate of the treatment group was 96.49%, significantly higher than that of control group ( 77.19%) ( P<0.01 ) . The time points that fever , cough and lung rales disappeared and hospi-talization time of the treatment group were significantly lower than those of control group ( P<0.01 ).The rate of adverse reactions in the treatment group was 7.02% and 3.51% in control group but without statistical difference ( P>0.05).Conclusion Erythromycin combined with azithro-mycin treatment for pediatric mycoplasma pneumonia is notably effective .