中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2015年
4期
248-251
,共4页
刘金鹏%于晓虹%杨国玲%宋智琦
劉金鵬%于曉虹%楊國玲%宋智琦
류금붕%우효홍%양국령%송지기
硬皮病,局部性%硬化萎缩苔藓%桥本病%疾病遗传易感性%病例报告
硬皮病,跼部性%硬化萎縮苔蘚%橋本病%疾病遺傳易感性%病例報告
경피병,국부성%경화위축태선%교본병%질병유전역감성%병례보고
Scleroderma,localized%Lichen sclerosus et atrophicus%Hashimoto disease%Genetic predisposition to disease%Case reports
报告姐妹俩同患硬斑病合并桥本甲状腺炎.例1女,64岁,颈前、躯干和双胫前皮疹5年,会阴部皮疹伴瘙痒4年,既往桥本甲状腺炎病史9年.体检:甲状腺Ⅰ度肿大,质韧,无突眼、胫前黏液水肿等表现.颈部、前胸淡红色斑片,后背部硬化萎缩,会阴部瓷白色斑块.皮损组织病理提示:(前胸)硬斑病,(外阴)硬化萎缩性苔藓.例2女,例1的妹妹,55岁,左乳下及腹部皮肤逐渐硬化萎缩4年,既往桥本甲状腺炎病史3年.体检:甲状腺Ⅰ度肿大,质韧,无突眼、胫前黏液水肿等表现.左乳下、腹部和后背中央皮肤色素减退,硬化萎缩.皮损组织病理提示:硬斑病.根据临床特点、组织病理、过碘酸-雪夫染色和甲状腺功能检查,2例均诊断为硬斑病合并桥本甲状腺炎.
報告姐妹倆同患硬斑病閤併橋本甲狀腺炎.例1女,64歲,頸前、軀榦和雙脛前皮疹5年,會陰部皮疹伴瘙癢4年,既往橋本甲狀腺炎病史9年.體檢:甲狀腺Ⅰ度腫大,質韌,無突眼、脛前黏液水腫等錶現.頸部、前胸淡紅色斑片,後揹部硬化萎縮,會陰部瓷白色斑塊.皮損組織病理提示:(前胸)硬斑病,(外陰)硬化萎縮性苔蘚.例2女,例1的妹妹,55歲,左乳下及腹部皮膚逐漸硬化萎縮4年,既往橋本甲狀腺炎病史3年.體檢:甲狀腺Ⅰ度腫大,質韌,無突眼、脛前黏液水腫等錶現.左乳下、腹部和後揹中央皮膚色素減退,硬化萎縮.皮損組織病理提示:硬斑病.根據臨床特點、組織病理、過碘痠-雪伕染色和甲狀腺功能檢查,2例均診斷為硬斑病閤併橋本甲狀腺炎.
보고저매량동환경반병합병교본갑상선염.례1녀,64세,경전、구간화쌍경전피진5년,회음부피진반소양4년,기왕교본갑상선염병사9년.체검:갑상선Ⅰ도종대,질인,무돌안、경전점액수종등표현.경부、전흉담홍색반편,후배부경화위축,회음부자백색반괴.피손조직병리제시:(전흉)경반병,(외음)경화위축성태선.례2녀,례1적매매,55세,좌유하급복부피부축점경화위축4년,기왕교본갑상선염병사3년.체검:갑상선Ⅰ도종대,질인,무돌안、경전점액수종등표현.좌유하、복부화후배중앙피부색소감퇴,경화위축.피손조직병리제시:경반병.근거림상특점、조직병리、과전산-설부염색화갑상선공능검사,2례균진단위경반병합병교본갑상선염.
Morphea complicated by Hashimoto's thyroiditis is reported in two sisters.Case 1:a 64-year-old female presented with skin rashes on the anterior neck,trunk and bilateral anterior shins for 5 years,itching skin rashes on the perineum for 4 years,and Hashimoto's thyroiditis for 9 years.Physical examination revealed grade 1 enlargement of firm thyroid gland without exophthalmos or pretibial myxedema.Dermatological examination showed pink patches on the neck and breast,sclerosis and atrophy of skin over the back,porcelain-white patches on the perineum.Histopathological findings suggested the diagnosis of morphea on the breast and lichen sclerosus et atrophicus on the perineum.Case 2:a 55-year-old female,who was the younger sister of case 1,suffered from gradual sclerosis and atrophy of skin in the left inframammary region and abdominal region for 4 years,as well as Hashimoto's thyroiditis for 3 years.Similarly,physical examination revealed grade 1 enlargement of firm thyroid gland without exophthalmos or pretibial myxedema.Hypopigmentation,sclerosis and atrophy of skin were observed in the left inframammary region,abdominal region and central back region.Histopathological examination suggested a diagnosis of morphea.According to the clinical and histopathological manifestations,periodic acid-Schiff staining and thyroid gland function test results,the 2 cases were both diagnosed as morphea complicated by Hashimoto's thyroiditis.
