中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2015年
4期
245-247
,共3页
周小勇%杨雪源%孙云芸%李新宇
週小勇%楊雪源%孫雲蕓%李新宇
주소용%양설원%손운예%리신우
银屑病%药物性肝损伤%治疗,临床研究性%双环醇%甘草酸二铵
銀屑病%藥物性肝損傷%治療,臨床研究性%雙環醇%甘草痠二銨
은설병%약물성간손상%치료,림상연구성%쌍배순%감초산이안
Psoriasis%Drug-induced liver injury%Therapies,investigational%Bicyclol%Diammonium glycyrrhizinate
目的 研究双环醇片对严重银屑病药物性肝损伤的保护作用.方法 将106例符合纳入标准的肝损伤银屑病患者随机分为双环醇组与甘草酸二铵组,分别给予口服双环醇片(25 mg,每日3次)和甘草酸二铵胶囊(150 mg,每日3次)治疗,疗程均为8周.比较2组治疗前后肝功能血清生化指标及综合疗效的组内和组间差异,观察记录用药后的不良反应.结果 双环醇组(52例)与甘草酸二铵组(51例)肝功能指标均得到了明显改善(P＜0.01),且双环醇组疗效优于甘草酸二铵组(P＜0.01),双环醇组与甘草酸二铵组的显效率分别为71.15％和47.06％(P＜0.05),有效率分别为84.62％和66.67％(P＜ 0.05).2组均未发生与研究药物有关的不良反应.结论 双环醇能有效缓解银屑病药物所致的肝损伤,且安全性好.
目的 研究雙環醇片對嚴重銀屑病藥物性肝損傷的保護作用.方法 將106例符閤納入標準的肝損傷銀屑病患者隨機分為雙環醇組與甘草痠二銨組,分彆給予口服雙環醇片(25 mg,每日3次)和甘草痠二銨膠囊(150 mg,每日3次)治療,療程均為8週.比較2組治療前後肝功能血清生化指標及綜閤療效的組內和組間差異,觀察記錄用藥後的不良反應.結果 雙環醇組(52例)與甘草痠二銨組(51例)肝功能指標均得到瞭明顯改善(P＜0.01),且雙環醇組療效優于甘草痠二銨組(P＜0.01),雙環醇組與甘草痠二銨組的顯效率分彆為71.15％和47.06％(P＜0.05),有效率分彆為84.62％和66.67％(P＜ 0.05).2組均未髮生與研究藥物有關的不良反應.結論 雙環醇能有效緩解銀屑病藥物所緻的肝損傷,且安全性好.
목적 연구쌍배순편대엄중은설병약물성간손상적보호작용.방법 장106례부합납입표준적간손상은설병환자수궤분위쌍배순조여감초산이안조,분별급여구복쌍배순편(25 mg,매일3차)화감초산이안효낭(150 mg,매일3차)치료,료정균위8주.비교2조치료전후간공능혈청생화지표급종합료효적조내화조간차이,관찰기록용약후적불량반응.결과 쌍배순조(52례)여감초산이안조(51례)간공능지표균득도료명현개선(P＜0.01),차쌍배순조료효우우감초산이안조(P＜0.01),쌍배순조여감초산이안조적현효솔분별위71.15％화47.06％(P＜0.05),유효솔분별위84.62％화66.67％(P＜ 0.05).2조균미발생여연구약물유관적불량반응.결론 쌍배순능유효완해은설병약물소치적간손상,차안전성호.
Objective To investigate the protective effect of bicyclol tablets on drug-induced hepatic injury in patients with severe psoriasis.Methods One hundred and six patients with severe psoriasis and drug-induced hepatic injury were enrolled in this study,and randomly divided into 2 groups:bicyclol group (53 cases) treated with oral bicyclol tablets (25 mg thrice a day) for 8 weeks,diammonium glycyrrhizinate group (53 cases) treated with diammonium glycyrrhizinate capsules (150 mg thrice a day) for 8 weeks.Serum biochemical indices of hepatic function were measured before and after treatment,therapeutic efficacy was evaluated,and adverse reactions were observed and recorded after treatment.Intergroup and intragroup differences in these parameters were assessed.Results During the treatment,3 patients were lost to follow up.After treatment,serum biochemical indices of hepatic function markedly improved in both the bicyclol group (52 cases) and diammonium glycyrrhizinate group (51 cases) (both P ＜ 0.01),and the bicyclol group showed a better treatment response than the diammonium glycyrrhizinate group (P ＜ 0.01).The marked response rate was 71.15％ and 47.06％ (P ＜ 0.05),and the response rate was 84.62％ and 66.67％ (P ＜ 0.05),respectively,in the bicyclol group and diammonium glycyrrhizinate group.No adverse reactions related to tested drugs were observed in either of the two groups.Conclusion Bicyclol can attenuate antipsoriatic drug-induced hepatic injury with good safety.
