CAJ | 학술논문

目的：评价阿托伐他汀钙对左心室舒张功能不全合并运动高血压患者运动血压及运动耐量的影响。方法选择左心室舒张功能不全并运动高血压患者60例随机分成治疗组30例和对照组30例。2组患者原治疗方案（降压及抗血小板治疗等）继续，治疗组加用阿托伐他汀钙20 mg，口服，每晚1次，对照组加用外形相同的安慰剂，疗程1年。2组治疗前后均进行运动心肺功能检查、运动血压测定和生活质量评定。结果治疗后，治疗组静息收缩压、脉压、运动最大收缩压降低，运动时间、运动当量、运动最大摄氧量、无氧阈值增大，生活质量评分改善，各指标相比治疗前差异均有统计学意义（ P＜0.05）；其与对照组治疗后的静息收缩压、运动最大收缩压、运动时间比较，差异有统计学意义（ P＜0.05）。结论阿托伐他汀钙治疗能有效降低左心室舒张功能不全并运动高血压患者的血压及运动最大收缩压，改善运动耐量，提高生活质量。
목적：평개아탁벌타정개대좌심실서장공능불전합병운동고혈압환자운동혈압급운동내량적영향。방법선택좌심실서장공능불전병운동고혈압환자60례수궤분성치료조30례화대조조30례。2조환자원치료방안（강압급항혈소판치료등）계속，치료조가용아탁벌타정개20 mg，구복，매만1차，대조조가용외형상동적안위제，료정1년。2조치료전후균진행운동심폐공능검사、운동혈압측정화생활질량평정。결과치료후，치료조정식수축압、맥압、운동최대수축압강저，운동시간、운동당량、운동최대섭양량、무양역치증대，생활질량평분개선，각지표상비치료전차이균유통계학의의（ P＜0.05）；기여대조조치료후적정식수축압、운동최대수축압、운동시간비교，차이유통계학의의（ P＜0.05）。결론아탁벌타정개치료능유효강저좌심실서장공능불전병운동고혈압환자적혈압급운동최대수축압，개선운동내량，제고생활질량。
Objective To evaluate the effect of atorvastatin on exercise blood pressure and exercise tolerance of patients with diastolic dysfunc-tion and hypertensive responses to exercise .Methods Sixty patients with diastolic dysfunction and hypertensive responses to exercise were se-lected and divided randomly into atorvastatin treatment group ( n =30 , atorvastatin 20 mg qn ) and control group ( n =30 ) .All patients con-tinued their original therapy .The course of treatment was one year .The data of cardiopulmonary exercise testing , exercise blood pressure meas-urement , quality of life assessment using heart failure questionnaire were compared before and after treatment . Results After treatment , the resting systolic blood pressure , pulse pressure , and the peak exercise systolic blood pressure were significantly decreased , and exercise time , metabolic equivalent ( METs ) , maximal oxygen uptake ( VO2 max ) and anaerobic threshold ( AT ) were increased , and and quality of life were improved compared with before treatment ( P <0.05 ) . There was statistical difference in the resting systolic blood pressure , the peak exercise systolic blood pressure , and the exercise time between two groups found ( P<0.05 ). Conclusion For patients with diastolic dysfunction and a hypertensive response to exercise , atorvastatin can effectively reduce the blood pressure and peak exercise systolic blood pressure , increase exercise tolerance and improve quality of life .