CAJ | 학술논문

目的：评价盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效及安全性。方法入选慢性牙周炎患者102例，随机分为对照组53例和试验组49例。对照组给予盐酸米诺环素软膏牙周袋内注射，每周1次，连续4周；试验组在对照组用药的基础上，加用替硝唑250 mg? d-1，连续4周。疗程结束后，比较2组患者的临床疗效及不良反应发生率。结果试验组的总有效率和对照组比较差异无统计学意义（99.11％ vs 97.50％， P＜0.05）；试验组显效率显著高于对照组（93.75％vs 63.33％， P＞0.05）；2组不良反应发生率比较差异无统计学意义（ P＞0.05）。结论盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎疗效显著，联合用药不增加不良反应发生率。
목적：평개염산미낙배소연고연합체초서치료만성아주염적림상료효급안전성。방법입선만성아주염환자102례，수궤분위대조조53례화시험조49례。대조조급여염산미낙배소연고아주대내주사，매주1차，련속4주；시험조재대조조용약적기출상，가용체초서250 mg? d-1，련속4주。료정결속후，비교2조환자적림상료효급불량반응발생솔。결과시험조적총유효솔화대조조비교차이무통계학의의（99.11％ vs 97.50％， P＜0.05）；시험조현효솔현저고우대조조（93.75％vs 63.33％， P＞0.05）；2조불량반응발생솔비교차이무통계학의의（ P＞0.05）。결론염산미낙배소연고연합체초서치료만성아주염료효현저，연합용약불증가불량반응발생솔。
Objective To evaluate the clinical effect and safety of mino-cycline combined with tinidazole on chronic periodontitis .Methods A total of 102 patients with chronic periodontitis were recruited in this pro-spective study and were divided into experiment group ( n=49 ) and con-trol group ( n =53 ) .Patients in control group were given minocycline once a week for 4 weeks and patients in experiment group were given mi-nocycline once a week plus tinidazole 250 mg per day for 4 weeks.The data of clinical efficacy and adverse reactions were evaluated after the treatment.Results The excellence rate were 93.8%and 63.3%in ex-periment and control group respectively , which indicated a higher rate in experiment group but with out statistical difference (P>0.05).And the adverse reactions such as nausea , itchy skin and dizziness were not statis-tically different between the two groups ( P<0.05 ).Conclusion Mino-cycline combined with tinidazole in the treatment of chronic periodontitis is effective , and not increasing the adverse reactions .