CAJ | 학술논문

目的：探讨新疆和田墨玉县维吾尔族农村女性人乳头状瘤病毒（human papilloma virus，HPV）感染现状及感染相关因素，为新疆地区子宫颈癌防治提供科学依据和指导。方法2013年5月15日－11月15日在和田墨玉县选取墨玉镇、喀尔赛乡、奎雅乡、扎瓦乡、雅瓦乡的21～60岁维吾尔族有性生活女性6000例，采用整群抽样的方法进行 HPV 检测及 HPV 感染相关因素的问卷调查，问卷内容包括基本信息、婚育状况、性行为等。由2名妇科医生采集标本并应用 careHPV 检测，以结果阳性判定为 HPV 感染，对数据进行统计学分析。结果共输入有效问卷6000份，研究人群 HPV 总感染率为8．4％。HPV 感染与年龄（χ2＝15．835，P ＜0．001）、婚姻状况（χ2＝12．805，P ＜0．001）、职业（χ2＝15．540，P ＜0．001）、文化程度（χ2＝25．224，P ＜0．001）、家庭收入（χ2＝5．637，P ＜0．05）有关。多因素 Logistic 回归分析显示：文化程度、同房频次与 HPV 感染存在关联（P ＜0．05）。结论新疆和田地区墨玉县维吾尔族农村妇女的 HPV 感染与年龄、婚姻状况、职业、同房频次存在一定关联。应该针对相关高危因素制定相应措施，规范人群行为，加强45岁以上妇女的筛查，进行有效干预。
목적：탐토신강화전묵옥현유오이족농촌녀성인유두상류병독（human papilloma virus，HPV）감염현상급감염상관인소，위신강지구자궁경암방치제공과학의거화지도。방법2013년5월15일－11월15일재화전묵옥현선취묵옥진、객이새향、규아향、찰와향、아와향적21～60세유오이족유성생활녀성6000례，채용정군추양적방법진행 HPV 검측급 HPV 감염상관인소적문권조사，문권내용포괄기본신식、혼육상황、성행위등。유2명부과의생채집표본병응용 careHPV 검측，이결과양성판정위 HPV 감염，대수거진행통계학분석。결과공수입유효문권6000빈，연구인군 HPV 총감염솔위8．4％。HPV 감염여년령（χ2＝15．835，P ＜0．001）、혼인상황（χ2＝12．805，P ＜0．001）、직업（χ2＝15．540，P ＜0．001）、문화정도（χ2＝25．224，P ＜0．001）、가정수입（χ2＝5．637，P ＜0．05）유관。다인소 Logistic 회귀분석현시：문화정도、동방빈차여 HPV 감염존재관련（P ＜0．05）。결론신강화전지구묵옥현유오이족농촌부녀적 HPV 감염여년령、혼인상황、직업、동방빈차존재일정관련。응해침대상관고위인소제정상응조시，규범인군행위，가강45세이상부녀적사사，진행유효간예。
Objective To investigate the current status of the Human Papilloma Virus (HPV)infection and the infection factors within rural Uyghur women in Moyu County,Hotan Region,and to provide quantita-tive support and guidance for the cervical cancer prevention in Xinjiang.Methods A survey on HPV tes-ting and HPV infection factors was conducted on a total of 6 000 Uyghur women with sexual activities aged 21 to 60 in Moyu,Dakar,Kuiya,Ayman al and Yawa of Moyu County,Hotan region,between June 15 and November 15,2013.Survey questions include basic information,obstetrical history,sexual activities. Specimens were collected by two gynecologists and positive CareHPV testing result was utilized to deter-mine HPV infection.EpiData was used to process raw data.Statistical analysis was conducted using SPSS 18.0.Chi-square test was used to test the differences in HPV infection rate and multivariate dichotomous. logistic regression analysis was conducted to evaluate the effects of different risk factors.Statistical signifi-cance was determined by (P ≤0.05).Results A total of 6 000 valid questionnaire copies was considered in the study.The population overall infection rate was 8.42%.Chi-square test result suggests that HPV in-fection correlates with age (χ2 =22.529,P =0.002),marital status (χ2 =13.970,P =0.001),occupation (χ2 =21.157 P <0.001),level of education (χ2 = 36.175,P <0.001),annual household income (χ2 =11.621,P =0.009),contraception situation (χ2 = 8.154,P =0.017),age when getting married (χ2 =20.360,P <0.001),number of marriages (χ2 = 11.605,P =0.003),number of sexual activities (χ2 =60.126,P <0.001).These factors are then incorporated into the multivariate logistic regression frame-work,Regression analysis shows that level of education,frequency of sexual activities,found correlated with HPV infection and are statistically significant (P <0.05).Conclusion HPV infection among rural Uyghur women in Hotan region of Xinjiang is found correlated with age,marital status,occupation,fre-quency of sexual activities.Measures should be taken targeted at the high risk factors.This suggests us that the sexual behavior of the population needs to be regulated and that the screening of menopause women,in particular aged 45 and above,should be conducted and monitored closely.