陕西中医
陝西中醫
협서중의
SHAANXI JOURNAL OF TRADITIONAL CHINESE MEDICINE
2015年
5期
616-618
,共3页
庞学丰%舒建龙%李玉玲%吴燕红%唐丽萍%刘欢%蒙宇华%冯玉青%雷宗尚%龙朝阳%廖键侥%林菊
龐學豐%舒建龍%李玉玲%吳燕紅%唐麗萍%劉歡%矇宇華%馮玉青%雷宗尚%龍朝暘%廖鍵僥%林菊
방학봉%서건룡%리옥령%오연홍%당려평%류환%몽우화%풍옥청%뢰종상%룡조양%료건요%림국
关节炎,实验性/中医药疗法%动物实验%大鼠
關節炎,實驗性/中醫藥療法%動物實驗%大鼠
관절염,실험성/중의약요법%동물실험%대서
Arthritis%experimental/traditional%Chinese medicine therapy%Animal experimentation Rats
目的：观察补肾抗风湿方药‐寒痹康汤对胶原诱导性关节炎（CIA ）大鼠血清血管内皮生长因子（VEGF）的影响。方法：采用牛Ⅱ型胶原蛋白和弗氏不完全佐剂诱导CIA 大鼠模型，以甲氨蝶呤为对照，观察不同剂量寒痹康汤对CIA大鼠的关节肿胀指数以及血清VEGF水平的影响。结果：寒痹康汤各剂量组大鼠的关节肿胀指数及升高的VEGF水平均降低（P＜0．01），其中中剂量寒痹康汤作用与甲氨蝶呤组相当（P＞0．05），高剂量寒痹康汤作用优于甲氨蝶呤（P＜0．01）。结论：补肾抗风湿方药‐寒痹康汤可以通过降低CIA大鼠血清VEGF水平而达到治疗类风湿关节炎的作用。
目的：觀察補腎抗風濕方藥‐寒痺康湯對膠原誘導性關節炎（CIA ）大鼠血清血管內皮生長因子（VEGF）的影響。方法：採用牛Ⅱ型膠原蛋白和弗氏不完全佐劑誘導CIA 大鼠模型，以甲氨蝶呤為對照，觀察不同劑量寒痺康湯對CIA大鼠的關節腫脹指數以及血清VEGF水平的影響。結果：寒痺康湯各劑量組大鼠的關節腫脹指數及升高的VEGF水平均降低（P＜0．01），其中中劑量寒痺康湯作用與甲氨蝶呤組相噹（P＞0．05），高劑量寒痺康湯作用優于甲氨蝶呤（P＜0．01）。結論：補腎抗風濕方藥‐寒痺康湯可以通過降低CIA大鼠血清VEGF水平而達到治療類風濕關節炎的作用。
목적：관찰보신항풍습방약‐한비강탕대효원유도성관절염（CIA ）대서혈청혈관내피생장인자（VEGF）적영향。방법：채용우Ⅱ형효원단백화불씨불완전좌제유도CIA 대서모형，이갑안접령위대조，관찰불동제량한비강탕대CIA대서적관절종창지수이급혈청VEGF수평적영향。결과：한비강탕각제량조대서적관절종창지수급승고적VEGF수평균강저（P＜0．01），기중중제량한비강탕작용여갑안접령조상당（P＞0．05），고제량한비강탕작용우우갑안접령（P＜0．01）。결론：보신항풍습방약‐한비강탕가이통과강저CIA대서혈청VEGF수평이체도치료류풍습관절염적작용。
ABSTRCAT Objective:To observe the clinical effect of the anti‐rheumatism drug– hanbikang decoction on the vascular endothelial growth factor (VEGF) in the serum of the rats with the collagen‐induced arthritis(CIA) .Methods :The CIA rats induced by the bovine type Ⅱ collagen and incomplete freund's adjuvant were taken as the experimental rats in both the control group and the experimental group .The contol group was treated with methotrexate while the experi‐mental groups with different doses were given hanbikang decoction .The clinical effect of different doses of hanbikang de‐cotion on the joint swelling index and the serum VEGF level of the CIA rats were observed .Results:The joint swelling index and the increased VEGF in the experimental groups were reduced(P < 0 .01) .There was no siginificant difference in the clinical effects between the experiemntal group with medium doses and the control group (P > 0 .05) .The condi‐tion of the CIA rats were significantly improved in the the experiemntal group with high doses compared with that in the control group(P<0 .01) .Conclusion :The anti‐rheumatism drug– hanbikang decoction is effective in treating the rheu‐matoid arthritis by reducing the serum VEGF of the CIA rats .
