CAJ | 학술논문

目的：评价MKK4基因-1304 T＞G（ rs3826392）单核苷酸多态性与结直肠癌发病风险的相关性。方法收集结直肠癌患者218例（试验组）和健康人群206例（对照组）的资料。用聚合酶链反应-限制性片段长度多态性分析法（ PCR-RLFP）检测患者-1304 T＞G位点的等位基因及基因型。结果与T等位基因相比，携带G等位基因的患者结直肠癌发病率显著降低（ P＜0.05）；与TT基因型相比，携带TG、GG、TG+GG基因型的患者结直肠癌发病率更低，差异均有统计学意义（ P＜0.05）。结论 MKK4基因-1304 T＞G单核苷酸多态性与结直肠癌的发病风险存在相关性。
목적：평개MKK4기인-1304 T＞G（ rs3826392）단핵감산다태성여결직장암발병풍험적상관성。방법수집결직장암환자218례（시험조）화건강인군206례（대조조）적자료。용취합매련반응-한제성편단장도다태성분석법（ PCR-RLFP）검측환자-1304 T＞G위점적등위기인급기인형。결과여T등위기인상비，휴대G등위기인적환자결직장암발병솔현저강저（ P＜0.05）；여TT기인형상비，휴대TG、GG、TG+GG기인형적환자결직장암발병솔경저，차이균유통계학의의（ P＜0.05）。결론 MKK4기인-1304 T＞G단핵감산다태성여결직장암적발병풍험존재상관성。
Objective To explore the MKK4 gene -1304 T >G ( rs3826392 ) single nucleotide polymorphisms and colorectal cancer risk . Methods The data of 218 patients with colorectal cancer ( experiment group) were enrolled in our hospital and 206 healthy people ( control group) were collected.The polymerase chain reaction -restriction frag-ment length polymorphism analysis ( PCR-RLFP) method was used to detect -1304 T>G loci alleles and genotypes .Results Compared with T allele , the allele of G could reduce the incidence of colorectal cancer , and the difference was statistically significant (P<0.05).Compared with TT, the genotype of TG , GG, TG +GG could reduce the incidence of colorectal cancer , and the difference was statistically significant (P<0.05).Conclusion The single nucleotide polymorphism of MKK4 gene-1304 T>G is correlated with the risk of colorectal cancer .