CAJ | 학술논문

目的评估窄谱中波紫外线(NB-UVB)治疗早期蕈样肉芽肿(MF)的疗效.方法采用回顾性研究方式,评估2003年1月至2013年12月期间收治的98例早期MF患者经NB-UVB治疗后的复发率、复发时间,观察该治疗方法的远期不良反应.结果随访至今获得完全缓解的52例患者,中位照射次数30次(18～87次),中位累积照射剂量24.16 J/cm2(9.11 ～ 108.86 J/cm2),中位随访时间41个月(11 ～ 90个月).14例(26.9％)曾出现复发,中位复发时间为维持治疗结束后8.2个月(3～60个月),复发患者再次接受NB-UVB治疗,依然能获得完全缓解.不良反应主要包括照射初期的皮肤红斑、瘙痒和照射后暂时性色素沉着.随访患者11～ 90个月,未发现有皮肤癌的发生.结论 NB-UVB光疗治疗早期MF疗效好,所有随访患者均未见皮肤癌发生,虽有一定复发性,但重复治疗依然有效.
목적 평고착보중파자외선(NB-UVB)치료조기심양육아종(MF)적료효.방법 채용회고성연구방식,평고2003년1월지2013년12월기간수치적98례조기MF환자경NB-UVB치료후적복발솔、복발시간,관찰해치료방법적원기불량반응.결과 수방지금획득완전완해적52례환자,중위조사차수30차(18～87차),중위루적조사제량24.16 J/cm2(9.11 ～ 108.86 J/cm2),중위수방시간41개월(11 ～ 90개월).14례(26.9％)증출현복발,중위복발시간위유지치료결속후8.2개월(3～60개월),복발환자재차접수NB-UVB치료,의연능획득완전완해.불량반응주요포괄조사초기적피부홍반、소양화조사후잠시성색소침착.수방환자11～ 90개월,미발현유피부암적발생.결론 NB-UVB광료치료조기MF료효호,소유수방환자균미견피부암발생,수유일정복발성,단중복치료의연유효.
Objective To evaluate the efficacy of narrow-band ultraviolet B (NB-UVB) for the treatment of early-stage mycosis fungoides (MF).Methods A retrospective study was performed on 98 patients with early-stage MF treated with NB-UVB from January 2003 to December 2013.The rate of and time to recurrence of MF were assessed,and long-term side effects were evaluated in these patients.Results Among 52 patients achieving complete remission,the median number of sessions of NB-UVB radiation was 30 (range,18-87),the median cumulative radiation dose was 24.16 J/cm2 (range,9.11-108.86 J/cm2),and the median follow-up duration was 41 months (range,11-90 months).Relapse occurred in 14 (26.9％) patients with the median time to recurrence being 8.2 months (range,3-60 months).The patients suffering from relapse achieved complete remission after treatment with NB-UVB again.Adverse reactions mainly included skin erythema and itching at the early stage of radiation,as well as temporary pigmentation after radiation.Cutaneous carcinoma occurred in none of these patients during 11-90 months of follow-up.Conclusions NB-UVB phototherapy appeared to be effective for the treatment of early-stage MF,and no cutaneous carcinoma occurred in these patients during the follow-up.Although MF may relapse in some cases,repeated NB-UVB phototherapy is still effective.