检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2015年
4期
337-340
,共4页
顾向明%黄阶胜%李莹莹%杜国有
顧嚮明%黃階勝%李瑩瑩%杜國有
고향명%황계성%리형형%두국유
同型半胱氨酸%C反应蛋白%急性脑血管病%脑梗死%脑出血%受试者工作特征曲线
同型半胱氨痠%C反應蛋白%急性腦血管病%腦梗死%腦齣血%受試者工作特徵麯線
동형반광안산%C반응단백%급성뇌혈관병%뇌경사%뇌출혈%수시자공작특정곡선
Homocysteine%C reactive protein%Acute cerebral vascular disease%Cerebral infarction%Intracerebral hemorrhage%Receiver operating characteristic curve
目的：研究同型半胱氨酸（Hcy）和C反应蛋白（CRP）在急性脑血管病（CVD）脑出血（ICH）和脑梗死（CI）中的临床应用价值。方法选取ICH患者68例，CI患者69例，以健康体检者117名作为正常对照组。采用循环酶法检测 Hcy，免疫增强比浊法测定CRP，对各组 Hcy、CRP 水平进行比较，并绘制受试者工作特征（ROC）曲线，研究Hcy、CRP与急性CVD的关系及临床应用价值。结果各组血清Hcy含量比较，CI组[15．1（13．1～19．0）μmol／L]和ICH组[13．3（11．2～16．3）μmol／L]均较正常对照组[11．0（9．1～12．9）μmol／L]明显增高（P＜0．01）；各组血清CRP含量比较，CI组[10．5（4．5～41．4）mg／L]和ICH组[30．2（12．3～72．2）mg／L]较正常对照组[0．1（0．1～0．1）mg／L]明显增高（P＜0．01）；各组血清Hcy和CRP异常检出率比较，CI和ICH组与正常对照组差异具有统计学意义（P＜0．01），且CI和ICH组血清Hcy异常检出率差异亦有统计学意义（P＜0．05）；在急性CVD中ROC曲线分析Hcy和CRP，ROC曲线下面积分别为0．762和0．967，诊断急性CVD有显著意义（P＝0．000），Hcy、CRP的含量越高诊断急性CVD的可能性越大。结论血Hcy和CRP水平在CVD患者较健康人群明显升高，且Hcy与CVD存在独立相关性；CRP是评价机体损伤的总体量化指标，在急性CVD的辅助诊断中具有一定的应用价值。
目的：研究同型半胱氨痠（Hcy）和C反應蛋白（CRP）在急性腦血管病（CVD）腦齣血（ICH）和腦梗死（CI）中的臨床應用價值。方法選取ICH患者68例，CI患者69例，以健康體檢者117名作為正常對照組。採用循環酶法檢測 Hcy，免疫增彊比濁法測定CRP，對各組 Hcy、CRP 水平進行比較，併繪製受試者工作特徵（ROC）麯線，研究Hcy、CRP與急性CVD的關繫及臨床應用價值。結果各組血清Hcy含量比較，CI組[15．1（13．1～19．0）μmol／L]和ICH組[13．3（11．2～16．3）μmol／L]均較正常對照組[11．0（9．1～12．9）μmol／L]明顯增高（P＜0．01）；各組血清CRP含量比較，CI組[10．5（4．5～41．4）mg／L]和ICH組[30．2（12．3～72．2）mg／L]較正常對照組[0．1（0．1～0．1）mg／L]明顯增高（P＜0．01）；各組血清Hcy和CRP異常檢齣率比較，CI和ICH組與正常對照組差異具有統計學意義（P＜0．01），且CI和ICH組血清Hcy異常檢齣率差異亦有統計學意義（P＜0．05）；在急性CVD中ROC麯線分析Hcy和CRP，ROC麯線下麵積分彆為0．762和0．967，診斷急性CVD有顯著意義（P＝0．000），Hcy、CRP的含量越高診斷急性CVD的可能性越大。結論血Hcy和CRP水平在CVD患者較健康人群明顯升高，且Hcy與CVD存在獨立相關性；CRP是評價機體損傷的總體量化指標，在急性CVD的輔助診斷中具有一定的應用價值。
목적：연구동형반광안산（Hcy）화C반응단백（CRP）재급성뇌혈관병（CVD）뇌출혈（ICH）화뇌경사（CI）중적림상응용개치。방법선취ICH환자68례，CI환자69례，이건강체검자117명작위정상대조조。채용순배매법검측 Hcy，면역증강비탁법측정CRP，대각조 Hcy、CRP 수평진행비교，병회제수시자공작특정（ROC）곡선，연구Hcy、CRP여급성CVD적관계급림상응용개치。결과각조혈청Hcy함량비교，CI조[15．1（13．1～19．0）μmol／L]화ICH조[13．3（11．2～16．3）μmol／L]균교정상대조조[11．0（9．1～12．9）μmol／L]명현증고（P＜0．01）；각조혈청CRP함량비교，CI조[10．5（4．5～41．4）mg／L]화ICH조[30．2（12．3～72．2）mg／L]교정상대조조[0．1（0．1～0．1）mg／L]명현증고（P＜0．01）；각조혈청Hcy화CRP이상검출솔비교，CI화ICH조여정상대조조차이구유통계학의의（P＜0．01），차CI화ICH조혈청Hcy이상검출솔차이역유통계학의의（P＜0．05）；재급성CVD중ROC곡선분석Hcy화CRP，ROC곡선하면적분별위0．762화0．967，진단급성CVD유현저의의（P＝0．000），Hcy、CRP적함량월고진단급성CVD적가능성월대。결론혈Hcy화CRP수평재CVD환자교건강인군명현승고，차Hcy여CVD존재독립상관성；CRP시평개궤체손상적총체양화지표，재급성CVD적보조진단중구유일정적응용개치。
Objective To study the application significance of homocysteine (Hcy) and C reactive protein(CRP) in acute cerebral vascular diseases ( CVD) , like intracerebral hemorrhage ( ICH) and cerebral infarction ( CI) .Methods There were ICH group (68 cases) and CI group (69 cases).A total of 117 healthy subjects were enrolled as healthy control group.Hcy was determined by cycle enzyme , CRP levels were measured by immuno-enhanced turbidimetry , and the means of Hcy and CRP were compared .The receiver operating characteristic ( ROC ) curve was drawn , and the relation between CRP and acute CVD and the clinical application significance were analyzed .Results The levels of Hcy in CI group [15.1(13.1-19.0)μmol/L] and ICH group [13.3(11.2-16.3)μmol/L] were higher than that in healthy control group [11.0(9.1-12.9)μmol/L, P<0.01].The levels of CRP in CI group [10.5(4.5-41.4)mg/L] and ICH group [30.2(12.3-72.2) mg/L] were higher than that in healthy control group [0.1(0.1-0.1) mg/L, P<0.01].Hcy and CRP abnormal rates in CI and ICH groups had significant difference compared with healthy control group (P<0.01), and Hcy abnormal rates between CI and ICH groups had difference (P<0.05).For acute CVD, the areas under ROC curve of Hcy and CRP were 0.762 and 0.967, and there was significance in the diagnosis of acute CVD (P=0.000).It could improve the possibility in the diagnosis of acute CVD .Conclusions Serum Hcy and CRP levels increase significantly in patients with CVD compared with healthy subjects , and Hcy and CVD exist independent correlation.CRP as an overall quantitative index to evaluate body injury has a certain significance in the diagnosis of acute CVD.
