中国药物应用与监测
中國藥物應用與鑑測
중국약물응용여감측
CHINESE JOURNAL OF DRUG APPLICATION AND MONITORING
2015年
2期
129-130
,共2页
环孢素注射液%过敏反应%药品不良反应
環孢素註射液%過敏反應%藥品不良反應
배포소주사액%과민반응%약품불량반응
Cyclosporine injection%Allergic reaction%Adverse drug reaction
1例31岁男性患者，确诊急性髓系白血病4个月，既往有维生素K1过敏史。行异基因外周血造血干细胞移植术，治疗期间使用环孢素注射液预防移植物抗宿主病（GVHD）治疗，输注该药20 min后，患者出现面颈部发红、心慌、气喘、呼吸短促等症状。立即停止输入环孢素注射液，给予抬高床头，吸氧，氧流量3 L·min-1，1 h后症状好转。次日为明确患者对环孢素注射液是否能耐受，再次给予环孢素注射液缓慢静滴，20 min后再次出现上述症状，改用他克莫司抗排异治疗，直至出院未再出现过敏反应。
1例31歲男性患者，確診急性髓繫白血病4箇月，既往有維生素K1過敏史。行異基因外週血造血榦細胞移植術，治療期間使用環孢素註射液預防移植物抗宿主病（GVHD）治療，輸註該藥20 min後，患者齣現麵頸部髮紅、心慌、氣喘、呼吸短促等癥狀。立即停止輸入環孢素註射液，給予抬高床頭，吸氧，氧流量3 L·min-1，1 h後癥狀好轉。次日為明確患者對環孢素註射液是否能耐受，再次給予環孢素註射液緩慢靜滴，20 min後再次齣現上述癥狀，改用他剋莫司抗排異治療，直至齣院未再齣現過敏反應。
1례31세남성환자，학진급성수계백혈병4개월，기왕유유생소K1과민사。행이기인외주혈조혈간세포이식술，치료기간사용배포소주사액예방이식물항숙주병（GVHD）치료，수주해약20 min후，환자출현면경부발홍、심황、기천、호흡단촉등증상。립즉정지수입배포소주사액，급여태고상두，흡양，양류량3 L·min-1，1 h후증상호전。차일위명학환자대배포소주사액시부능내수，재차급여배포소주사액완만정적，20 min후재차출현상술증상，개용타극막사항배이치료，직지출원미재출현과민반응。
One 31-year-old male patient with allergic history of vitamin K1 was diagnosed with acute myeloid leukemia 4 months ago. He accepted allogeneic peripheral blood hematopoietic stem cell transplantation. Cyclosporine injection was applied to prevent graft-versus-host disease (GVHD). Twenty minutes after the infusion of cyclosporine injection, the patient appeared the face and neck redness, lfustered, asthma, shortness of breath and other symptoms. Cyclosporine injection was stopped immediately and the head of the patient was elevated. After the inhalation of oxygen with 3 L·min-1, the patient felt better. The next day he was given cyclosporine injection again to test whether the patient tolerated cyclosporine. The same symptoms appeared again. So tacrolimus was used to prevent GVHD. No allergic reactions happened until he was discharged from the hospital.
