CAJ | 학술논문

目的：评价糖化血红蛋白（HbA1c）与非糖尿病（DM）急性ST段抬高型心肌梗死（STEMI）患者冠状动脉病变严重程度的关系。方法：记录111例急性STEMI并接受直接经皮冠状动脉造影的非DM患者的临床特点、HbA1c、空腹血糖（FBG）、血脂等生化指标，根据患者的HbA1c值分为两组，A组（HbA1c≤5.6%，52例）、B组（HbA1c 5.7%～6.4%，59例）。使用Gensini评分来评估冠状动脉病变的严重度。结果：111例患者中男性占82%，吸烟占73.9%，高血压占51.4%，多支病变发生率为76.6%。B组患者FBG、Gensini评分及多支病变所占比例均明显高于A组。HbA1c和Gensini评分呈正相关（P=0.006）。多元逐步回归分析显示在非DM急性STEMI患者中， HbA1c及年龄是Gensini评分的独立危险因素（P＜0.05）。结论：HbA1c是非DM急性STEMI患者冠状动脉病变严重度的独立危险因素。
목적：평개당화혈홍단백（HbA1c）여비당뇨병（DM）급성ST단태고형심기경사（STEMI）환자관상동맥병변엄중정도적관계。방법：기록111례급성STEMI병접수직접경피관상동맥조영적비DM환자적림상특점、HbA1c、공복혈당（FBG）、혈지등생화지표，근거환자적HbA1c치분위량조，A조（HbA1c≤5.6%，52례）、B조（HbA1c 5.7%～6.4%，59례）。사용Gensini평분래평고관상동맥병변적엄중도。결과：111례환자중남성점82%，흡연점73.9%，고혈압점51.4%，다지병변발생솔위76.6%。B조환자FBG、Gensini평분급다지병변소점비례균명현고우A조。HbA1c화Gensini평분정정상관（P=0.006）。다원축보회귀분석현시재비DM급성STEMI환자중， HbA1c급년령시Gensini평분적독립위험인소（P＜0.05）。결론：HbA1c시비DM급성STEMI환자관상동맥병변엄중도적독립위험인소。
Objective: To evaluate the relationship between HbA1c levels and the severity of coronary artery stenosis in patients with acute ST-segment-elevation myocardial infarction(STEMI) without diabetes mellitus.Methods:111 cases of acute STEMI and received percutaneous coronary angiography patients with non DM who obtained the clinical characteristics,HbA1c,fasting blood glucose(FBG),blood lipids and other biochemical indicators,according to the patient's HbA1c values were divided into two groups, group A (HbA1c=5.6%, group B (52 cases), HbA1c 5.7%~6.4%, 59 cases). The use of the Gensini score to assess the severity of coronary artery lesions.Results:In the 111 patients, 82% male, smoking accounted for 73.9% of hypertension accounted for 51.4%, multivessel disease incidence rate is 76.6%. Group B patients with FBG, Gensini score and the proportion of multivessel disease were significantly higher than those in group A.HbA1c and Gensini scores were positively (P=0.006). Multiple stepwise regression analysis showed that in the non DM patients with acute STEMI, HbA1c and age were independent risk factors of Gensini score (P<0.05).Conclusion:HbA1c were the independent risk factors for the severity of coronary artery stenosis in patients with acute STEMI without diabetes mellitus.