中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2015年
3期
224-226
,共3页
付晓葆%吴永全%王宏宇%刘金波%连艳凯
付曉葆%吳永全%王宏宇%劉金波%連豔凱
부효보%오영전%왕굉우%류금파%련염개
冠心病%左室舒张功能%Gensini积分%左室舒张末压力
冠心病%左室舒張功能%Gensini積分%左室舒張末壓力
관심병%좌실서장공능%Gensini적분%좌실서장말압력
Coronary artery disease%Left ventricular diastolic function%Gensini score%Left ventricular end diastolic pressure
目的：观察冠心病(CHD)患者冠状动脉病变程度与左室舒张功能之间的关系。方法：81例疑诊CHD行冠脉造影并且左室射血分数正常的患者分为CHD组（56例）和对照组（25例）。冠状动脉造影前行左室压力记录测定左室舒张末期压力（LVEDP），CHD患者行Gensini积分评估冠脉病变程度。结果：CHD组患糖尿病、高血压比例高于对照组，LVEDP较对照组升高（P=0.005）。对包括糖尿病、高血压、LVEDP在内的参数行多元Logistic回归，结果显示两组间LVEDP差别仍然有统计学意义（P=0.039）。CHD患者Gensini积分≥100组LVEDP明显高于＜50组（P=0.032），CHD三支病变组LVEDP同单支病变组相比明显升高（P=0.023）。Pearson单因素相关分析显示LVEDP与冠状动脉Gensini积分成正相关（r=0.355,P=0.007）。结论：射血分数正常的CHD患者左室舒张功能受损，并随冠脉病变范围和程度增加而恶化。
目的：觀察冠心病(CHD)患者冠狀動脈病變程度與左室舒張功能之間的關繫。方法：81例疑診CHD行冠脈造影併且左室射血分數正常的患者分為CHD組（56例）和對照組（25例）。冠狀動脈造影前行左室壓力記錄測定左室舒張末期壓力（LVEDP），CHD患者行Gensini積分評估冠脈病變程度。結果：CHD組患糖尿病、高血壓比例高于對照組，LVEDP較對照組升高（P=0.005）。對包括糖尿病、高血壓、LVEDP在內的參數行多元Logistic迴歸，結果顯示兩組間LVEDP差彆仍然有統計學意義（P=0.039）。CHD患者Gensini積分≥100組LVEDP明顯高于＜50組（P=0.032），CHD三支病變組LVEDP同單支病變組相比明顯升高（P=0.023）。Pearson單因素相關分析顯示LVEDP與冠狀動脈Gensini積分成正相關（r=0.355,P=0.007）。結論：射血分數正常的CHD患者左室舒張功能受損，併隨冠脈病變範圍和程度增加而噁化。
목적：관찰관심병(CHD)환자관상동맥병변정도여좌실서장공능지간적관계。방법：81례의진CHD행관맥조영병차좌실사혈분수정상적환자분위CHD조（56례）화대조조（25례）。관상동맥조영전행좌실압력기록측정좌실서장말기압력（LVEDP），CHD환자행Gensini적분평고관맥병변정도。결과：CHD조환당뇨병、고혈압비례고우대조조，LVEDP교대조조승고（P=0.005）。대포괄당뇨병、고혈압、LVEDP재내적삼수행다원Logistic회귀，결과현시량조간LVEDP차별잉연유통계학의의（P=0.039）。CHD환자Gensini적분≥100조LVEDP명현고우＜50조（P=0.032），CHD삼지병변조LVEDP동단지병변조상비명현승고（P=0.023）。Pearson단인소상관분석현시LVEDP여관상동맥Gensini적분성정상관（r=0.355,P=0.007）。결론：사혈분수정상적CHD환자좌실서장공능수손，병수관맥병변범위화정도증가이악화。
Objective: To observe the relationship between the severity of coronary artery disease and left ventricular diastolic function in patients with coronary heart disease (CHD).Methods:81 patients with suspected CHD undergoing coronary angiography and normal left ventricular ejection fraction were divided into CHD group (56 cases) and control group (25 cases). Left ventricular end diastolic pressure (LVEDP) based on left ventricular pressure recording before coronary angiography and Gensini score assessing for the severity of coronary artery stenosis in CHD patients were measured.Results:In CHD group, the prevalence of diabetes and hypertension was higher than that of the control group, LVEDP was higher than the control group (P=0.005). The result of multiple Logistic regression, including diabetes, hypertension and LVEDP, showed it remain significant difference in LVEDP (P=0.039) between two groups (P=0.039). LVEDP in group of Gensini score≥100 was significantly higher than that in group of Gensini score<50 (P=0.032), LVEDP is obviously higher in group of three vascular obstructive than one vascular obstructive (P=0.023). Single factor analysis showed LVEDP was positively correlated with Gensini score (r=0.355,P=0.007).Conclusion:Left ventricular diastolic function was impaired and associated with the extent and severity of coronary artery stenosis in CHD patients with normal ejection fraction.
