中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2015年
3期
246-247
,共2页
慢性阻塞性肺疾病%同型半胱氨酸%一氧化氮%IL-8%超敏-C反应蛋白
慢性阻塞性肺疾病%同型半胱氨痠%一氧化氮%IL-8%超敏-C反應蛋白
만성조새성폐질병%동형반광안산%일양화담%IL-8%초민-C반응단백
Chronic obstructive pulmonary disease%Homocysteine%Nitric oxide%IL-8%High sensitivity-C reactive protein
目的:检测慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)患者的血浆同型半胱氨酸(Hcy)、一氧化氮(NO)、白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)水平,探讨其对COPD的作用机制。方法:AECOPD患者200例,年龄及其性别与其匹配的健康对照组180例。测定200例AECOPD患者血浆Hcy、NO、IL-8、hs-CRP水平,并与健康对照组进行比较。结果:①NC组、AECOPD组一般临床资料的比较显示两组患者的性别、年龄、血压比较差异无统计学意义(P>0.05)。②NC、AECOPD两组临床资料比较显示AECOPD组患者血浆总同型半胱氨酸(tHcy)、IL-8及hs-CRP水平明显高于NC组(P<0.01)。NO与NC组比较显著性降低(P<0.01)。③tHcy与IL-8及hs-CRP呈正相关,与NO呈负相关。结论:COPD患者血浆存在高Hcy和低NO水平,同时伴有IL-8升高,三者参与了COPD的发生与发展,是衡量COPD病情严重程度和判断患者的疗效及预后的重要指标。Hcy通过多种途径参与COPD的发生与发展,减少Hcy的药物可能能延缓COPD的进展。
目的:檢測慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)患者的血漿同型半胱氨痠(Hcy)、一氧化氮(NO)、白細胞介素-8(IL-8)、超敏C反應蛋白(hs-CRP)水平,探討其對COPD的作用機製。方法:AECOPD患者200例,年齡及其性彆與其匹配的健康對照組180例。測定200例AECOPD患者血漿Hcy、NO、IL-8、hs-CRP水平,併與健康對照組進行比較。結果:①NC組、AECOPD組一般臨床資料的比較顯示兩組患者的性彆、年齡、血壓比較差異無統計學意義(P>0.05)。②NC、AECOPD兩組臨床資料比較顯示AECOPD組患者血漿總同型半胱氨痠(tHcy)、IL-8及hs-CRP水平明顯高于NC組(P<0.01)。NO與NC組比較顯著性降低(P<0.01)。③tHcy與IL-8及hs-CRP呈正相關,與NO呈負相關。結論:COPD患者血漿存在高Hcy和低NO水平,同時伴有IL-8升高,三者參與瞭COPD的髮生與髮展,是衡量COPD病情嚴重程度和判斷患者的療效及預後的重要指標。Hcy通過多種途徑參與COPD的髮生與髮展,減少Hcy的藥物可能能延緩COPD的進展。
목적:검측만성조새성폐질병(COPD)급성가중기(AECOPD)환자적혈장동형반광안산(Hcy)、일양화담(NO)、백세포개소-8(IL-8)、초민C반응단백(hs-CRP)수평,탐토기대COPD적작용궤제。방법:AECOPD환자200례,년령급기성별여기필배적건강대조조180례。측정200례AECOPD환자혈장Hcy、NO、IL-8、hs-CRP수평,병여건강대조조진행비교。결과:①NC조、AECOPD조일반림상자료적비교현시량조환자적성별、년령、혈압비교차이무통계학의의(P>0.05)。②NC、AECOPD량조림상자료비교현시AECOPD조환자혈장총동형반광안산(tHcy)、IL-8급hs-CRP수평명현고우NC조(P<0.01)。NO여NC조비교현저성강저(P<0.01)。③tHcy여IL-8급hs-CRP정정상관,여NO정부상관。결론:COPD환자혈장존재고Hcy화저NO수평,동시반유IL-8승고,삼자삼여료COPD적발생여발전,시형량COPD병정엄중정도화판단환자적료효급예후적중요지표。Hcy통과다충도경삼여COPD적발생여발전,감소Hcy적약물가능능연완COPD적진전。
Objective: Detection of chronic obstructive pulmonary disease (COPD) (AECOPD) in patients with acute exacerbation of plasma homocysteine (Hcy), nitric oxide (NO), IL-8, high sensitive C reactive protein (hs-CRP) level, and to explore its action mechanism on COPD. Methods: 200 cases of AECOPD patients, age and gender matched healthy control group of 180 cases. Determination of plasma in 200 patients with AECOPD Hcy, NO, IL-8, HS and CRP levels, and compared with control group.Results:Group NC, group AECOPD with clinical data comparison shows that two groups of patients with gender, age, blood pressure difference was not significant (P>0.05). The NC, AECOPD two groups of clinical data comparison indicated that the AECOPD group patients plasma tHcy, IL-8 and hs-CRP levels were significantly higher than that of group NC (P<0.01). NO and NC group was significantly lower (P<0.01). The tHcy and IL-8 and hs-CRP were positively correlated, negatively related with NO.Conclusion:Plasma COPD in patients with high Hcy and low NO levels, accompanied by the increase of IL-8, the three participated in the occurrence and development of COPD, is an important index to evaluate the severity of COPD and judge curative effect and prognosis of the patients. The occurrence and development of Hcy involved in COPD through a variety of ways, reduce Hcy drugs may delay the progress of COPD.