CAJ | 학술논문

为探索通过检测非结构蛋白（ NSPs）抗体的方法评价口蹄疫疫苗纯度的可行性，用不同纯化工艺制备口蹄疫O型、亚洲1型、A型三价灭活疫苗，重复免疫牛至少3次后，定期检测NSP s的ELISA抗体并统计分析抗体情况。结果显示，高度纯化疫苗组的NSPs抗体阴性率远高于普通纯化疫苗组，表明通过检测NSP s抗体评价口蹄疫疫苗纯度可以作为质量控制的一种方法。
위탐색통과검측비결구단백（ NSPs）항체적방법평개구제역역묘순도적가행성，용불동순화공예제비구제역O형、아주1형、A형삼개멸활역묘，중복면역우지소3차후，정기검측NSP s적ELISA항체병통계분석항체정황。결과현시，고도순화역묘조적NSPs항체음성솔원고우보통순화역묘조，표명통과검측NSP s항체평개구제역역묘순도가이작위질량공제적일충방법。
To examine the feasibility of evaluating the purity of the foot-and-mouth disease vaccine by testing the nonstructural proteins ELISA antibodies, the type O, type Asia 1, type A inactivated foot-and-mouth disease vaccines that were purified and processed differently immunized the cattle repeatedly at least three times. Hereafter, the nonstructural proteins ELISA antibodies were monitored regularly, statistics and analysis on the results of the NSPs ELISA antibodies were collected. It has shown that the negative rate of the nonstructural proteins ELISA antibodies of the highly purified vaccine group is significantly higher than that of averagely purified vaccine group. It is suggested that estimating the purity of the foot-and-mouth disease vaccine by means of the NSPs ELISA antibodies detected can be a method to control the qualities.