CAJ | 학술논문

目的：探讨利多卡因在气管导管套囊中应用的有效性。方法：①体外渗透研究：选取60个套囊，随机分为三组，各20个，a组(2%盐酸利多卡因，ID：7.5)、b组(1.73%碳酸利多卡因,ID：7.5)和c组(1.73%碳酸利多卡因,ID：8.0)，测定利多卡因的渗透能力。②临床研究：选择ASAⅠ～Ⅱ级择期手术患者80例，随机分为四组，各20例，A组(对照，空气)、B组(双蒸水)、C组(2%盐酸利多卡因)、D组(1.73%碳酸利多卡因)，分别向套囊内加入受试品，观察患者在围拔管期对气管导管的耐受性，HR、MAP、SPO2，以及咳嗽、咽痛、声嘶、痰量、恶心、呕吐等并发症的发生率。结果：①体外渗透研究表明：b组、c组能渗透套囊，a组不能；渗透量与时间成正比；套囊的型号大小对渗透能力无显著影响（P＞0.05）。②患者对气管导管的耐受性：D组明显高于A、B、C三组（P＜0.05）；患者的咳嗽、咽痛、声嘶、血流动力学的波动：D组较A、B、C三组明显减少（P＜0.05）；痰量、术后恶心、呕吐：A、B、C、D四组患者均无明显改善（P＞0.05）。结论：碳酸利多卡因在临床气管导管套囊中应用技术是可行的和有效的。
목적：탐토리다잡인재기관도관투낭중응용적유효성。방법：①체외삼투연구：선취60개투낭，수궤분위삼조，각20개，a조(2%염산리다잡인，ID：7.5)、b조(1.73%탄산리다잡인,ID：7.5)화c조(1.73%탄산리다잡인,ID：8.0)，측정리다잡인적삼투능력。②림상연구：선택ASAⅠ～Ⅱ급택기수술환자80례，수궤분위사조，각20례，A조(대조，공기)、B조(쌍증수)、C조(2%염산리다잡인)、D조(1.73%탄산리다잡인)，분별향투낭내가입수시품，관찰환자재위발관기대기관도관적내수성，HR、MAP、SPO2，이급해수、인통、성시、담량、악심、구토등병발증적발생솔。결과：①체외삼투연구표명：b조、c조능삼투투낭，a조불능；삼투량여시간성정비；투낭적형호대소대삼투능력무현저영향（P＞0.05）。②환자대기관도관적내수성：D조명현고우A、B、C삼조（P＜0.05）；환자적해수、인통、성시、혈류동역학적파동：D조교A、B、C삼조명현감소（P＜0.05）；담량、술후악심、구토：A、B、C、D사조환자균무명현개선（P＞0.05）。결론：탄산리다잡인재림상기관도관투낭중응용기술시가행적화유효적。
Objective: To explore the effectiveness of application of lidocaine in endotracheal tube cuff.Methods:①The study permeation in vitro:60 cuffs were randomly divided into three groups, each of 20, a group (2% lidocaine hydrochloride, ID:7.5), b group (lidocaine carbonate ID:7.5, 1.73%) and c group (lidocaine carbonate ID:8.0, 1.73%),determination of lidocaine inifltration capacity.②The clinical study: 80 ASAⅠ~Ⅱ patients scheduled for surgery were randomly divided into four groups, 20 cases each,group A(control, air),group B(double distilled water),group C(2% lidocaine hydrochloride), group D (1.73% lidocaine carbonate),injected above materials into the cuffs. observed in patients with extubation of tracheal catheter tolerance, HR, MAP, SPO2, and sore throat, hoarseness, cough, sputum volume, nausea, vomiting and the incidence of complications.Results:①The in vitro penetration studies show that: b group, c group were able to penetrate the cuffs, a group could not; permeability is proportional to the time; sleeve bag size had no signiifcant effect on inifltration capacity (P>0.05).②The patients tolerated on endotracheal tube: D group was signiifcantly higher than that of A, B, C three groups (P<0.05); patients with cough, sore throat, hoarseness, hemodynamic lfuctuations: D group compared with the A, B, C three groups decreased signiifcantly (P<0.05); sputum volume, postoperative nausea and vomiting: A, B, C, D of four groups were no signiifcant improvement (P>0.05).Conclusion: In the clinical application of lidocaine carbonate technology endotracheal tube cuff is feasible and effective.