CAJ | 학술논문

目的：探讨颈—股脉搏波速度（cfPWV）与冠状动脉病变严重程度之间的关系。 　　方法：共入选接受首次冠状动脉（冠脉）造影检查的患者319例。对所有患者的冠脉造影结果进行SYNTAX评分，评价其冠脉病变程度。118例冠脉造影显示未见≥50%狭窄作为对照组，其余201例患者依据SYNTAX评分分为低SYNTAX组（1~17.5分，n=96）和高SYNTAX组（18~72分，n=105）。测量入选患者的cfPWV。采用等级Logistic回归方法，分析SYNTAX评分与cfPWV的关系。采用ROC曲线分析cfPWV预测SYNTAX评分结果的准确性。 　　结果：在校正了年龄、性别、肥胖、吸烟、冠心病家族史、平均血压、总胆固醇、高密度脂蛋白胆固醇、踝臂指数、高血压、高脂血症、糖尿病等因素后，SYNTAX评分与cfPWV显著相关（OR=1.24，P=0.006）。进一步分析显示， cfPWV与SYNTAX评分的关系在男性、非肥胖、吸烟、糖尿病以及非高血压患者中更为密切。cfPWV预测SYNTAX评分≥33分具有较高准确性（ROC曲线下面积0.703）。 　　结论：作为评估主动脉僵硬度的“金标准”，cfPWV与冠脉病变程度有相关性。
목적：탐토경—고맥박파속도（cfPWV）여관상동맥병변엄중정도지간적관계。 　　방법：공입선접수수차관상동맥（관맥）조영검사적환자319례。대소유환자적관맥조영결과진행SYNTAX평분，평개기관맥병변정도。118례관맥조영현시미견≥50%협착작위대조조，기여201례환자의거SYNTAX평분분위저SYNTAX조（1~17.5분，n=96）화고SYNTAX조（18~72분，n=105）。측량입선환자적cfPWV。채용등급Logistic회귀방법，분석SYNTAX평분여cfPWV적관계。채용ROC곡선분석cfPWV예측SYNTAX평분결과적준학성。 　　결과：재교정료년령、성별、비반、흡연、관심병가족사、평균혈압、총담고순、고밀도지단백담고순、과비지수、고혈압、고지혈증、당뇨병등인소후，SYNTAX평분여cfPWV현저상관（OR=1.24，P=0.006）。진일보분석현시， cfPWV여SYNTAX평분적관계재남성、비비반、흡연、당뇨병이급비고혈압환자중경위밀절。cfPWV예측SYNTAX평분≥33분구유교고준학성（ROC곡선하면적0.703）。 　　결론：작위평고주동맥강경도적“금표준”，cfPWV여관맥병변정도유상관성。
Objective: To explore the relationship between carotid-femoral pulse wave velocity (cfPWV) and the severity of coronary artery lesions measured by SYNTAX score. Methods:A total of 319 patients who received the ifrst time coronary angiography were studied. SYNTAX score evaluation was conducted to assess the severity of coronary lesions and the patients were divided into 3 groups:Control group, the subjects without coronary stenosis≥50%, n=118, the rest 201 patients were divided as Low SYNTAX score (1-17.5) group, n=96 and High SYNTAX score (18-72) group, n=105. The cfPWV was measured in all patients, the relationship between SYNTAX score and cfPWV was studied by Ordinal logistic regression analysis, the accuracy for cfPWV predicting SYNTAX scoring was assessed by ROC analysis. Results: With the adjusted factors of age, gender, obesity, smoking, family history of CAD, mean blood pressure, TC, HDL-C, ankle-brachial index (ABI), hypertension, hyperlipidaemia and diabetes, SYNTAX score was obviously related to cfPWV (OR=1.24, P=0.006). Further analysis for both High and Low SYNTAX score groups, the relationship between cfPWV and SYNTAX score was more close in patients with male gender, non-obesity, smoking, diabetes and non-hypertension. The accuracy for cfPWV predicting SYNTAX scoring had the higher sensitivity in patients with SYNTAX≥33 (ROC=0.703). Conclusion: As golden standard for measuring aortic stiffness, cfPWV is related to the severity of coronary artery lesions in relevant patients.