中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2015年
4期
570-571,572
,共3页
李小月%査勇%霍佩珍%沈继龙
李小月%査勇%霍珮珍%瀋繼龍
리소월%사용%곽패진%침계룡
抗环瓜氨酸抗体%类风湿因子%类风湿性关节炎
抗環瓜氨痠抗體%類風濕因子%類風濕性關節炎
항배과안산항체%류풍습인자%류풍습성관절염
Anti-cyclic citrullinated peptide antibody%Rheumatoid factor%Rheumatoid arthritis
目的：探讨抗环瓜氨酸肽（抗-CCP）抗体和类风湿因子（RF）在类风湿关节炎（RA）中的诊断价值。方法分别检测抗 CCP 抗体（酶联免疫吸附实验）、RF 及 CRP（免疫比浊法）、ESR（魏式法）在 RA 组、非 RA 组和健康人中的表达并比较分析。结果RA 组和非 RA 组 CRP、ESR 表达水平无显著性差异（P ＞0．05），而 RA 组 RF 表达显著高于非 RA 组，两者有显著性差异（P ＜0．01）；RA 组抗 CCP 抗体和 RF 阳性率明显高于非 RA 组和对照组，数据经统计学比较差异有统计学意义（P ＜0．01）。抗 CCP 抗体的敏感性为72．72％，特异性为92．68％；RF 的敏感性为86．36％，特异性为85．37％；抗 CCP 抗体和 RF 联合检测敏感性为63．64％，特异性为95．12％。结论在 RA 诊断中，抗-CCP 有较高的特异性，RF 有较高的敏感性，两者联合检测有利于早期诊断 RA。
目的：探討抗環瓜氨痠肽（抗-CCP）抗體和類風濕因子（RF）在類風濕關節炎（RA）中的診斷價值。方法分彆檢測抗 CCP 抗體（酶聯免疫吸附實驗）、RF 及 CRP（免疫比濁法）、ESR（魏式法）在 RA 組、非 RA 組和健康人中的錶達併比較分析。結果RA 組和非 RA 組 CRP、ESR 錶達水平無顯著性差異（P ＞0．05），而 RA 組 RF 錶達顯著高于非 RA 組，兩者有顯著性差異（P ＜0．01）；RA 組抗 CCP 抗體和 RF 暘性率明顯高于非 RA 組和對照組，數據經統計學比較差異有統計學意義（P ＜0．01）。抗 CCP 抗體的敏感性為72．72％，特異性為92．68％；RF 的敏感性為86．36％，特異性為85．37％；抗 CCP 抗體和 RF 聯閤檢測敏感性為63．64％，特異性為95．12％。結論在 RA 診斷中，抗-CCP 有較高的特異性，RF 有較高的敏感性，兩者聯閤檢測有利于早期診斷 RA。
목적：탐토항배과안산태（항-CCP）항체화류풍습인자（RF）재류풍습관절염（RA）중적진단개치。방법분별검측항 CCP 항체（매련면역흡부실험）、RF 급 CRP（면역비탁법）、ESR（위식법）재 RA 조、비 RA 조화건강인중적표체병비교분석。결과RA 조화비 RA 조 CRP、ESR 표체수평무현저성차이（P ＞0．05），이 RA 조 RF 표체현저고우비 RA 조，량자유현저성차이（P ＜0．01）；RA 조항 CCP 항체화 RF 양성솔명현고우비 RA 조화대조조，수거경통계학비교차이유통계학의의（P ＜0．01）。항 CCP 항체적민감성위72．72％，특이성위92．68％；RF 적민감성위86．36％，특이성위85．37％；항 CCP 항체화 RF 연합검측민감성위63．64％，특이성위95．12％。결론재 RA 진단중，항-CCP 유교고적특이성，RF 유교고적민감성，량자연합검측유리우조기진단 RA。
Objective To explore the diagnostic value of anti-cyclic citrullinated peptide (anti-CCP)antibody and rheumatoid factor (RF)in rheumatoid arthritis.Methods Enzyme-linked immunosorbent assay (ELISA)and immuno-turbidimetric assay and Westergrem assay were employed to analyze the expressing levels of anti-CCP antibody,RF, CRP and ESR for RA,non-RA and healthy control groups respectively.Results the expressing levels of CRP and ESR of RA and non-RA groups were not statistically significant (P>0.05),while the expressing level of RF of RA group was much higher than that of the non-RA group,and the difference was statistically significant (P <0.01);the positive rate of anti-CCP antibody and RF for RA group was higher than that of the non-RA and control groups,and the differ-ence was statistically significant (P <0.01).The sensitivity of anti-CCP antibody and RF were 72.72% and 86.36%, respectively;the specificity of anti-CCP antibody and RF were 92.68% and 85.37%,respectively.The joint-detection sensitivity and specificity for anti-CCP antibody and RF were 63.64% and 95.12,respectively.Conclusion In the diag-nosis of RA,anti-CCP detection is highly specific,RF is highly sensitive,joint detection of anti-CCP and RF is conducive for the early diagnosis of RA.
