CAJ | 학술논문

目的：探讨 P57和 P63在完全性与部分性水泡状胎块中的表达差异及意义。方法回顾性分析100例水泡状胎块，汇总其临床资料，观察病理组织学特征，应用免疫组织组化方法检测 P57及 P63的表达的情况，并依据两者的表达进行分型，其中完全性水泡状胎块76例，部分性水泡状胎块24例。结果P57在完全性水泡状胎块中未见阳性表达，在部分性水泡状胎块中75％的病例出现明确的阳性表达，25％的病例出现弱的、不明确的表达，P63在完全性水泡状胎块中9．2％的病例出现阳性表达，而在部分性水泡状胎块中的表达率为83．3％，两者差异有统计学意义（P ＜0．05）。结论完全水泡状胎块与部分性水泡状胎块从临床表现、影像学表现、病理组织形态学等方面鉴别较为困难，联合应用 P57和 P63，可以对完全性水泡状胎块和部分性水泡状胎块进行准确的鉴别诊断，从而对该疾病的治疗及预后的预测均具有重大意义。
목적：탐토 P57화 P63재완전성여부분성수포상태괴중적표체차이급의의。방법회고성분석100례수포상태괴，회총기림상자료，관찰병리조직학특정，응용면역조직조화방법검측 P57급 P63적표체적정황，병의거량자적표체진행분형，기중완전성수포상태괴76례，부분성수포상태괴24례。결과P57재완전성수포상태괴중미견양성표체，재부분성수포상태괴중75％적병례출현명학적양성표체，25％적병례출현약적、불명학적표체，P63재완전성수포상태괴중9．2％적병례출현양성표체，이재부분성수포상태괴중적표체솔위83．3％，량자차이유통계학의의（P ＜0．05）。결론완전수포상태괴여부분성수포상태괴종림상표현、영상학표현、병리조직형태학등방면감별교위곤난，연합응용 P57화 P63，가이대완전성수포상태괴화부분성수포상태괴진행준학적감별진단，종이대해질병적치료급예후적예측균구유중대의의。
Objective To investigate the differential expression in complete and partial hydatidiform moles and sig-nificance of P57 and P63.Methods We selected 100 cases of hydatidiform mole were retrospectively analyzed,summa-rized the clinical data,histopathology of characteristics ,and the application of immunohistochemical method to detect P57 and P63 expression in the tissues,and the expression of nuclear typing ,including 76 cases of complete hydatidiform mole,part 24 cases of hydatidiform mole.Results The positive expression of P57 was negative in complete hydatidiform mole ,in partial hydatidiform mole75%cases positive expression,25% cases appeared weak,not clear expression.the expression of P63 ,in complete hydatidiform mole and partial hydatidiform moles was 9.2% and 83.3%,with statistical significant differ-ence between the two groups(P<0.05),and the expression of P63 more clearly.Conclusion Complete hydatidiform mole par-tial hydatidiform mole from the clinical manifestations,imaging features,histopathology,identification is difficult ,combined ap-plication of P57 and P63 can accurately identify the complete hydatidiform mole and partial hydatidiform mole,forecast for the diagnosis ,treatment and prognosis of the disease is of great significance.