CAJ | 학술논문

目的：探讨妊高症早期肾损伤检测视黄醇结合蛋白浓度水平的意义，为临床诊治提供依据。方法选择2011年2月-2013年10月确诊为妊高症的孕妇100例设为试验组，选择同期健康孕检妊娠者100例设为对照组，分别检测视黄醇结合蛋白和胱抑素 C 的浓度水平，对结果进行分析。结果试验组孕妇的视黄醇结合蛋白和胱抑素 C浓度水平明显高于对照组，差异显著（P ＜0．05），且随着患者病情的加重呈现递增的趋势；试验各组患者孕妇的视黄醇结合蛋白和胱抑素 C 的阳性检出率分别两两比较均无明显差异（P ＞0．05），且患者的视黄醇结合蛋白阳性检出率均超过85．0％；临床确诊结果与视黄醇结合蛋白检测结果的 Kappa 一致性分析得出 Kappa 值等于0．86。结论视黄醇结合蛋白是一种同胱抑素 C 一样对妊高症早期肾损伤具有诊断价值的有效指标，具有较高的灵敏度和临床符合性。
목적：탐토임고증조기신손상검측시황순결합단백농도수평적의의，위림상진치제공의거。방법선택2011년2월-2013년10월학진위임고증적잉부100례설위시험조，선택동기건강잉검임신자100례설위대조조，분별검측시황순결합단백화광억소 C 적농도수평，대결과진행분석。결과시험조잉부적시황순결합단백화광억소 C농도수평명현고우대조조，차이현저（P ＜0．05），차수착환자병정적가중정현체증적추세；시험각조환자잉부적시황순결합단백화광억소 C 적양성검출솔분별량량비교균무명현차이（P ＞0．05），차환자적시황순결합단백양성검출솔균초과85．0％；림상학진결과여시황순결합단백검측결과적 Kappa 일치성분석득출 Kappa 치등우0．86。결론시황순결합단백시일충동광억소 C 일양대임고증조기신손상구유진단개치적유효지표，구유교고적령민도화림상부합성。
Objective To explore the application meaning of the early kidney injury of the Pregnancy-induced hyper-tension syndrome diagnosis by the retinol binding protein testing,and providing the basis for clinical diagnosis and treatment.Methods Choosing 100 cases of the Pregnancy-induced hypertension syndrome patients for the experimental group and 100 cases healthy check-upes for the control group,testing the retinol binding protein and Cystatin C,analy-zing the results.Results Compared with the control group,there were significantly increased of retinol binding protein and Cystatin Cof the experimental group (P <0.05),and along with the deterioration of the patients showed a trend of increasing.There were no significant differences between the retinol binding protein and Cystatin C of the positive rate of the experimental group(p>0.05),and the positive rate of the retinol binding protein of the experimental group was more than 85.00%.The Kappa of the retinol binding protein results and the clinical diagnosis was 0.86.Conclusion There is a good indicators of the retinol binding protein whcih as the Cystatin C for the early kidney injury of the Preg-nancy-induced hypertension syndrome diagnosis,and which has high sensitivity and clinical compliance.