CAJ | 학술논문

miRNA的正常表达调控对于维持细胞机能处于一种稳定状态至关重要。最近，科学家们发现尽管人体血液中存在大量核糖核酸酶(RNA酶)，但在健康人和患者的细胞外血液中均存在着游离的miRNA。大多数这些循环miRNA被包含于与脂质或脂蛋白复合物之中，如凋亡小体(apoptotic bodies)、微泡(microvesicles)、外来体(exosomes)等，因此在血液中能耐RNA酶，具有良好的稳定性。癌症患者血液中的循环miRNA有可能成为一种新的潜在生物标志物，用于癌症的诊断和预后。本篇文章总结了一些在癌症患者中具有诊断、预后及治疗意义的miRNAs，同时期待更多关于循环miRNA分泌和纳入机制的研究。
miRNA적정상표체조공대우유지세포궤능처우일충은정상태지관중요。최근，과학가문발현진관인체혈액중존재대량핵당핵산매(RNA매)，단재건강인화환자적세포외혈액중균존재착유리적miRNA。대다수저사순배miRNA피포함우여지질혹지단백복합물지중，여조망소체(apoptotic bodies)、미포(microvesicles)、외래체(exosomes)등，인차재혈액중능내RNA매，구유량호적은정성。암증환자혈액중적순배miRNA유가능성위일충신적잠재생물표지물，용우암증적진단화예후。본편문장총결료일사재암증환자중구유진단、예후급치료의의적miRNAs，동시기대경다관우순배miRNA분비화납입궤제적연구。
In the past several years,the importance of microRNA (miRNA)in can-cer cel s has been recognized.Proper control of miRNA expression is essential for maintaining a steady state of the cel ular machinery.Recently,it was discovered that extracel ular miRNAs circulate in the blood of both healthy and diseased patients,although ribonuclease is present in both plasma and serum.Most of the circulating miRNAs are included in lipid or lipoprotein complexes,such as apoptotic bodies,microvesicles,or exosomes,and are highly stable.The existence of circulating mi-RNAs in the blood of cancer patients has raised the possibility that miRNAs may as a novel diagnostic marker.However,the secretory mechanism and biological function,as wel as the meaning of the existence of extracel ular miRNAs,remain largely unc-ear.In this review,the usefulness of circulating miRNA for cancer diagnosis,progno-sis,and therapeutics were summarized.Furthermore,a mechanism for the secretion and incorporation of miRNA into the cel s are expected.