CAJ | 학술논문

阿尔茨海默病(Alzheimer’s disease, AD)是一种常见的中老年神经退行性疾病,它会引起人记忆、认知及行为障碍。近年来,对阿尔茨海默病的发病机制及药物研究已引起全世界人们的高度重视,并取得了一定进展。但是到目前为止,还没有研制出任何一种有效的针对性治疗药物。综合目前的研究结果,一般认为淀粉样蛋白病变对大脑产生的毒性是AD发生的主要病因。本文对红茶中的主要功效成分以及近年来对该成分的研究进行概括,分析了红茶中功能性成分对阿尔茨海默病潜在的调控作用。并且从体内和体外两方面,对红茶中有效成分作用于AD机制的研究进展进行了综述。研究表明,红茶对阿尔茨海默病有潜在的预防及调控作用,其活性成分茶黄素可能起到重要作用。
아이자해묵병(Alzheimer’s disease, AD)시일충상견적중노년신경퇴행성질병,타회인기인기억、인지급행위장애。근년래,대아이자해묵병적발병궤제급약물연구이인기전세계인문적고도중시,병취득료일정진전。단시도목전위지,환몰유연제출임하일충유효적침대성치료약물。종합목전적연구결과,일반인위정분양단백병변대대뇌산생적독성시AD발생적주요병인。본문대홍다중적주요공효성분이급근년래대해성분적연구진행개괄,분석료홍다중공능성성분대아이자해묵병잠재적조공작용。병차종체내화체외량방면,대홍다중유효성분작용우AD궤제적연구진전진행료종술。연구표명,홍다대아이자해묵병유잠재적예방급조공작용,기활성성분다황소가능기도중요작용。
Alzheimer’s disease(AD)is a common complex human neurodegenerative disease that results in the patients’ memory, cognition and behavior disorders. In recent years, the studies of the pathogenesis of Alzheimer's disease and drugs have caused a worldwide attention, and have made some progress. But so far, it has not yet developed any kinds of effective therapeutic drugs. Comprehensive study results showed that the toxicity of pathological changes of amyloid peptide to the brain was responsible for the AD. This paper summarized the primary functional components of black tea and recent studies on the compositions. Besides, the potential regulatory effects of black tea extracts or the functional ingredients in it on Alzheimer's disease were analyzed. As well, the mechanisms of black tea extracts or some certain elements was reported for the prevention and regulation of AD bothin vivo andin vitro. It was considered that black tea had the potential to protect against AD, and its theaflavins might be the most important component.