新疆医学
新疆醫學
신강의학
XINJIANG MEDICAL JOURNAL
2015年
4期
421-424
,共4页
周玲%张德莲%李南方%木拉力别克·黑扎提
週玲%張德蓮%李南方%木拉力彆剋·黑扎提
주령%장덕련%리남방%목랍력별극·흑찰제
双氢克尿噻%卡托普利%尼群地平%高血压%血浆离子
雙氫剋尿噻%卡託普利%尼群地平%高血壓%血漿離子
쌍경극뇨새%잡탁보리%니군지평%고혈압%혈장리자
chydrochlorothiazide%captopril%nitrendipine%hypertension%plasma ions
目的：探讨小剂量双氢克尿噻为基础的、联合卡托普利或尼群地平的阶梯降压干预对新疆农牧区高血压患者血压、血浆钾、钠、镁、钙水平的影响。方法通过流行病学调查筛查未接受药物降压治疗的高血压患者。对符合入选标准的高血压患者给予小剂量双氢克尿噻为基础的联合阶梯降压干预。降压治疗的0周、2周、4周、6周、3月进行血压、心率监测。0周、3月采集患者静脉血检测血钾、钠、镁、钙等指标。结果（1）以小剂量双氢克尿噻为基础的不同降压药物组合方案均使高血压患者的血压水平得到明显降低，双氢克尿噻组、双氢克尿噻+卡托普利组、双氢克尿噻+尼群地平组、双氢克尿噻+卡托普利+尼群地平组四种降压方案的血压降低幅度分别为16.7/11.87 mmHg、25.38/14.17 mmHg、20.01/10.21 mmHg、18.42/11.22 mmHg，均具有统计学意义（P＜0.05）。（2）以小剂量双氢克尿噻为基础的不同降压药物组合方案干预前后，高血压患者血钾、镁、钙水平无明显改变（P＞0.05）。降压干预后血钠水平呈下降趋势。结论以小剂量双氢克尿噻为基础的、联合卡托普利或尼群地平的阶梯降压干预不仅能使新疆农牧区高血压患者血压得到显著降低，而且对患者血钾等血浆离子水平无不良影响。
目的：探討小劑量雙氫剋尿噻為基礎的、聯閤卡託普利或尼群地平的階梯降壓榦預對新疆農牧區高血壓患者血壓、血漿鉀、鈉、鎂、鈣水平的影響。方法通過流行病學調查篩查未接受藥物降壓治療的高血壓患者。對符閤入選標準的高血壓患者給予小劑量雙氫剋尿噻為基礎的聯閤階梯降壓榦預。降壓治療的0週、2週、4週、6週、3月進行血壓、心率鑑測。0週、3月採集患者靜脈血檢測血鉀、鈉、鎂、鈣等指標。結果（1）以小劑量雙氫剋尿噻為基礎的不同降壓藥物組閤方案均使高血壓患者的血壓水平得到明顯降低，雙氫剋尿噻組、雙氫剋尿噻+卡託普利組、雙氫剋尿噻+尼群地平組、雙氫剋尿噻+卡託普利+尼群地平組四種降壓方案的血壓降低幅度分彆為16.7/11.87 mmHg、25.38/14.17 mmHg、20.01/10.21 mmHg、18.42/11.22 mmHg，均具有統計學意義（P＜0.05）。（2）以小劑量雙氫剋尿噻為基礎的不同降壓藥物組閤方案榦預前後，高血壓患者血鉀、鎂、鈣水平無明顯改變（P＞0.05）。降壓榦預後血鈉水平呈下降趨勢。結論以小劑量雙氫剋尿噻為基礎的、聯閤卡託普利或尼群地平的階梯降壓榦預不僅能使新疆農牧區高血壓患者血壓得到顯著降低，而且對患者血鉀等血漿離子水平無不良影響。
목적：탐토소제량쌍경극뇨새위기출적、연합잡탁보리혹니군지평적계제강압간예대신강농목구고혈압환자혈압、혈장갑、납、미、개수평적영향。방법통과류행병학조사사사미접수약물강압치료적고혈압환자。대부합입선표준적고혈압환자급여소제량쌍경극뇨새위기출적연합계제강압간예。강압치료적0주、2주、4주、6주、3월진행혈압、심솔감측。0주、3월채집환자정맥혈검측혈갑、납、미、개등지표。결과（1）이소제량쌍경극뇨새위기출적불동강압약물조합방안균사고혈압환자적혈압수평득도명현강저，쌍경극뇨새조、쌍경극뇨새+잡탁보리조、쌍경극뇨새+니군지평조、쌍경극뇨새+잡탁보리+니군지평조사충강압방안적혈압강저폭도분별위16.7/11.87 mmHg、25.38/14.17 mmHg、20.01/10.21 mmHg、18.42/11.22 mmHg，균구유통계학의의（P＜0.05）。（2）이소제량쌍경극뇨새위기출적불동강압약물조합방안간예전후，고혈압환자혈갑、미、개수평무명현개변（P＞0.05）。강압간예후혈납수평정하강추세。결론이소제량쌍경극뇨새위기출적、연합잡탁보리혹니군지평적계제강압간예불부능사신강농목구고혈압환자혈압득도현저강저，이차대환자혈갑등혈장리자수평무불량영향。
Objective To explore effects of small dose hydrochlorothiazide-based and captopril and nitrendipine-combined blood pressure (BP) lowering intervention on plasma potassium, sodium, magnesium and calcium of hypertensive patients in farming and pastoral areas of Xinjiang. Methods hypertensive population not receiving antihypertensive medications was screened using epidemiological investigations. Small dose hydrochlorothiazide-based combined blood pressure lowering intervention was performed to those who fulfilled the inclusion criteria. Blood pressure and heart rate were detected in 0, 2, 4, 6 and 12weeks. Blood samples were collected to detect plasma potassium, sodium, magnesium and calcium in 0 and 12weeks. Results 1) small dose hydrochlorothiazide-based blood pressure lowering intervention consisted of different antihypertensive medications had the blood pressure of these population lowered significantly. BP lowering scopes of hydrochlorothiazide group, hydrochlorothiazide+captopril group,hydrochlorothiazide+nitrendipine group and hydrochlorothiazide+captopril+nitrendipine group were 16.7/11.87mmHg, 25.38/14.17mmHg, 20.01/10.21mmHg, and 18.42/11.22mmHg respectively, all with statistical significance (p<0.05). 2) Before and after small dose hydrochlorothiazide-based blood pressure lowering intervention consisted of different antihypertensive medications, there was no significant change found in levels of plasma potassium, magnesium and calcium of hypertensive patients (p>0.05). However, plasma sodium showed a tendency to decrease after intervention. Conclusion Asmall dose hydrochlorothiazide-based, captopril or nitrendipine-combined blood pressure lowering intervention not only lowered BP, also had no reverse effects on plasma ions as potassium of hypertensive patients in farming and pastoral areas of Xinjiang.
