医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
35期
48-50
,共3页
关媛%戴芳芳%高燕玲%李贵庆
關媛%戴芳芳%高燕玲%李貴慶
관원%대방방%고연령%리귀경
中西医结合%绝经后骨质疏松%左归丸%雌激素治疗%骨质疏松
中西醫結閤%絕經後骨質疏鬆%左歸汍%雌激素治療%骨質疏鬆
중서의결합%절경후골질소송%좌귀환%자격소치료%골질소송
combine traditional Chinese and Western medicine%postmenopausal osteoporosis%zuogui pil%Estrogen therapy%osteoporosis
目的：探讨左归丸治疗绝经后骨质疏松的临床疗效。方法研究对象随机分为3组，A组：服用钙尔奇D及阿法骨化醇；B组：在A组用药的基础上，加用替勃龙；C组：在A组用药的基础上加用左归丸加味。疗程6个月。比较治疗后骨折风险因子，血生化指标，骨密度及中医症候疗效的变化。结果B组与C组在主要部位骨质疏松骨折概率及髋部骨折概率均低于比A组，差异有统计学意义，B组与C组比较，差异无统计学意义。B组与C组在股骨颈及腰椎L1-4骨密度上均高于A组，且B组骨密度高于C组，差异有统计学意义。B组与C组的ALP，β-CTX，PINP均低于对照组，两组比较无统计学意义。B组的E2明显高于C组及A组，差异有统计学意义，C组与A组比较，差异无统计学意义。B组与C组的总有效率均高于较A组，差异有统计学意义，B组与C组比较，差异无统计学意义。结论左归丸对绝经后骨质疏松有一定的疗效，当由于各种原因无法应用雌激素时，可选择左归丸加味辩证论治。
目的：探討左歸汍治療絕經後骨質疏鬆的臨床療效。方法研究對象隨機分為3組，A組：服用鈣爾奇D及阿法骨化醇；B組：在A組用藥的基礎上，加用替勃龍；C組：在A組用藥的基礎上加用左歸汍加味。療程6箇月。比較治療後骨摺風險因子，血生化指標，骨密度及中醫癥候療效的變化。結果B組與C組在主要部位骨質疏鬆骨摺概率及髖部骨摺概率均低于比A組，差異有統計學意義，B組與C組比較，差異無統計學意義。B組與C組在股骨頸及腰椎L1-4骨密度上均高于A組，且B組骨密度高于C組，差異有統計學意義。B組與C組的ALP，β-CTX，PINP均低于對照組，兩組比較無統計學意義。B組的E2明顯高于C組及A組，差異有統計學意義，C組與A組比較，差異無統計學意義。B組與C組的總有效率均高于較A組，差異有統計學意義，B組與C組比較，差異無統計學意義。結論左歸汍對絕經後骨質疏鬆有一定的療效，噹由于各種原因無法應用雌激素時，可選擇左歸汍加味辯證論治。
목적：탐토좌귀환치료절경후골질소송적림상료효。방법연구대상수궤분위3조，A조：복용개이기D급아법골화순；B조：재A조용약적기출상，가용체발룡；C조：재A조용약적기출상가용좌귀환가미。료정6개월。비교치료후골절풍험인자，혈생화지표，골밀도급중의증후료효적변화。결과B조여C조재주요부위골질소송골절개솔급관부골절개솔균저우비A조，차이유통계학의의，B조여C조비교，차이무통계학의의。B조여C조재고골경급요추L1-4골밀도상균고우A조，차B조골밀도고우C조，차이유통계학의의。B조여C조적ALP，β-CTX，PINP균저우대조조，량조비교무통계학의의。B조적E2명현고우C조급A조，차이유통계학의의，C조여A조비교，차이무통계학의의。B조여C조적총유효솔균고우교A조，차이유통계학의의，B조여C조비교，차이무통계학의의。결론좌귀환대절경후골질소송유일정적료효，당유우각충원인무법응용자격소시，가선택좌귀환가미변증론치。
Objective:To evaluate the curative effect of zuogui pil for postmenopausal osteoporosis.Methods:Subjects were randomly divided into 3 groups, group A:taking calcium, odd and afar ossification alcohol;Group B: on the basis of group A ,add up tibolone;Group C: on the basis of group A,add up zuogui pil.Treatment for 6 months.Compared with fracture risk factors after treatment, blood biochemical indicators, the changes of bone mineral density and TCM symptoms curative effect.Results: In the main part of osteoporosis fracture,group B and group C have lower risk of hip fracture than in group A, the difference was statisticaly significant, when compared group B with group C, there was no statisticaly significant difference.Bone mineral density in the femoral neck and lumbar spine and in BMD at L1-4 ,Group B and group C were higher than in group A, and group B was higher than that of group C, the difference was statisticaly significant. ALP,β-CTX, PINP in group B and group C are lower than the control group, the difference was statisticaly significant, comparing the two groups has no statistical significance. E2 of group B was obviously higher than that of group C and group A, the difference was statisticaly significant,while group C compared with group A, there was no statisticaly significant difference.The total effective rate of group B and C group were higher than the group A, the difference was statisticaly significant,group B compared with group C, there was no statisticaly significant difference. Conclusion: On postmenopausal osteoporosis zuogui pil have certain curative effect, when estrogen can't be used for various reasons,we can choose zuogui pil to add and subtract the dialectical treatment.
