医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2015年
16期
18-19,20
,共3页
急性白血病%真菌感染%预后影响因素%Logistic回归
急性白血病%真菌感染%預後影響因素%Logistic迴歸
급성백혈병%진균감염%예후영향인소%Logistic회귀
Acute leukemia%Fungal infection%Prognostic factors%Logistic regression analysis
目的：探讨急性白血病合并真菌感染的临床特点及影响预后的因素。方法回顾性分析2007年8月~2014年5月我院血液科收治的急性白血病合并真菌感染患者的临床资料，对影响预后的因素采用单因素字2检验及多因素L ogistic回归分析。结果急性白血病患者真菌感染发生率为27.54%，病死率11.46豫；真菌培养阳性者58例次，共检出82株真菌，酵母菌69株(占84.15%)，霉菌9株，(占10.98%)；感染部位以呼吸道(占64.63%)、消化道(占23.13%)、口腔(占8.84%)多见；经Logistic回归分析人选的年龄≥60岁、中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭四因素在治疗有效组和无效组之间有显著性差异(<0.05)。中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭三因素在存活组和死亡组间有显著性差异(<0.05)。结论肺部、消化道、口腔是急性白血病合并真菌感染主要感染部位，白色念珠菌感染占首位，年龄≥60岁、中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭是急性白血病合并真菌感染治疗无效的不良预后因素。其中中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭是急性白血病合并真菌感染死亡的危险因素。
目的：探討急性白血病閤併真菌感染的臨床特點及影響預後的因素。方法迴顧性分析2007年8月~2014年5月我院血液科收治的急性白血病閤併真菌感染患者的臨床資料，對影響預後的因素採用單因素字2檢驗及多因素L ogistic迴歸分析。結果急性白血病患者真菌感染髮生率為27.54%，病死率11.46豫；真菌培養暘性者58例次，共檢齣82株真菌，酵母菌69株(佔84.15%)，黴菌9株，(佔10.98%)；感染部位以呼吸道(佔64.63%)、消化道(佔23.13%)、口腔(佔8.84%)多見；經Logistic迴歸分析人選的年齡≥60歲、中性粒細胞缺乏≥2w、有既往真菌感染病史、閤併多器官功能衰竭四因素在治療有效組和無效組之間有顯著性差異(<0.05)。中性粒細胞缺乏≥2w、有既往真菌感染病史、閤併多器官功能衰竭三因素在存活組和死亡組間有顯著性差異(<0.05)。結論肺部、消化道、口腔是急性白血病閤併真菌感染主要感染部位，白色唸珠菌感染佔首位，年齡≥60歲、中性粒細胞缺乏≥2w、有既往真菌感染病史、閤併多器官功能衰竭是急性白血病閤併真菌感染治療無效的不良預後因素。其中中性粒細胞缺乏≥2w、有既往真菌感染病史、閤併多器官功能衰竭是急性白血病閤併真菌感染死亡的危險因素。
목적：탐토급성백혈병합병진균감염적림상특점급영향예후적인소。방법회고성분석2007년8월~2014년5월아원혈액과수치적급성백혈병합병진균감염환자적림상자료，대영향예후적인소채용단인소자2검험급다인소L ogistic회귀분석。결과급성백혈병환자진균감염발생솔위27.54%，병사솔11.46예；진균배양양성자58례차，공검출82주진균，효모균69주(점84.15%)，매균9주，(점10.98%)；감염부위이호흡도(점64.63%)、소화도(점23.13%)、구강(점8.84%)다견；경Logistic회귀분석인선적년령≥60세、중성립세포결핍≥2w、유기왕진균감염병사、합병다기관공능쇠갈사인소재치료유효조화무효조지간유현저성차이(<0.05)。중성립세포결핍≥2w、유기왕진균감염병사、합병다기관공능쇠갈삼인소재존활조화사망조간유현저성차이(<0.05)。결론폐부、소화도、구강시급성백혈병합병진균감염주요감염부위，백색념주균감염점수위，년령≥60세、중성립세포결핍≥2w、유기왕진균감염병사、합병다기관공능쇠갈시급성백혈병합병진균감염치료무효적불량예후인소。기중중성립세포결핍≥2w、유기왕진균감염병사、합병다기관공능쇠갈시급성백혈병합병진균감염사망적위험인소。
Objective To investigate the clinical characteristics and prognosis fungal Infection in patients with acute leukemia. Methods The cases of fungal infection in acute leukemia patients ,between 2007 /8 and 2014/05,were col ected retrospectively from hematology department of binzhou people Hospital. The factors which influence the prognostic factors to be investigated .Chi-square test and Logistic regression analysis were used for statistics. Results The incidence of fungal infection in acute leukemia was 27.54%,and mortality rate was 11.46%.The frequently presented fungus was the saccharomyces(84.15%),then mould(10.98%).The common site of infection is the respiratory tract(64.63%)、intestinal tract(23.13%),oral cavity(8.84%),According to multivariate Logistic regression analysis, only age、the duration of neutropenia≥2weeks,history of fungus infection multiple organ failure are the the factors associated with the curative ef ect of fungal infections( <0.05).The duration of neutropenia≥2weeks,history of fungus infection multiple organ failure are the the factors associated with the mortality of fungal infections ( <0.05).Conclusion The common site of fungal infection is the respiratory tract intestinal tract oral cavity;The frequently presented fungus was the saccharomyces,age≥60、the duration of neutropenia ≥2weeks history of fungus infection multiple organ failure are the the factors associated with the curative ef ect of fungal infections.The duration of neutropenia ≥2weeks、history of fungus infection、multiple organ failure are the the factors associated with the mortality of fungal infections.
