医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2015年
3期
557-559
,共3页
糖尿病 ,2型/诊断%羟基胆骨化醇类/血液%动脉粥样硬化%颈动脉
糖尿病 ,2型/診斷%羥基膽骨化醇類/血液%動脈粥樣硬化%頸動脈
당뇨병 ,2형/진단%간기담골화순류/혈액%동맥죽양경화%경동맥
Diabetes Mellitus,Type 2/DI%Hydroxycholecalciferols/BL%Atherosclerosis%Carotid Arteries
【目的】探讨新诊断2型糖尿病（T2DM ）患者血清25‐羟维生素D [25（O H ）D ]与颈动脉粥样硬化的关系。【结果】依据颈动脉内膜中层厚度（CIM T ），将118例新诊断T2DM 患者分为非颈动脉粥样硬化（NCAS ）组和颈动脉粥样硬化（CAS）组。比较两组患者25（OH）D以及其它生化指标的差异，并使用logistic回归分析新诊断T2DM患者CAS发生的危险因素。【结果】CAS组餐后2 h血糖（2hPG）、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇（LDL‐C）、C反应蛋白（CRP）水平均显著高于NCAS组，而其25（OH）D水平低于NCAS组，差异均有统计学意义（均 P ＜0．05）；相关分析显示CIMT 与年龄、2hPG、HbA1c、LDL‐C、CRP呈正相关，与25（OH）D水平呈负相关；logistic回归分析显示2hPG、LDL‐C、CRP和25（O H ）D是CAS的独立危险因素。【结论】25（O H ）D是CAS的独立危险因素，其与新诊断T2DM患者CAS发生发展密切相关。
【目的】探討新診斷2型糖尿病（T2DM ）患者血清25‐羥維生素D [25（O H ）D ]與頸動脈粥樣硬化的關繫。【結果】依據頸動脈內膜中層厚度（CIM T ），將118例新診斷T2DM 患者分為非頸動脈粥樣硬化（NCAS ）組和頸動脈粥樣硬化（CAS）組。比較兩組患者25（OH）D以及其它生化指標的差異，併使用logistic迴歸分析新診斷T2DM患者CAS髮生的危險因素。【結果】CAS組餐後2 h血糖（2hPG）、糖化血紅蛋白（HbA1c）、低密度脂蛋白膽固醇（LDL‐C）、C反應蛋白（CRP）水平均顯著高于NCAS組，而其25（OH）D水平低于NCAS組，差異均有統計學意義（均 P ＜0．05）；相關分析顯示CIMT 與年齡、2hPG、HbA1c、LDL‐C、CRP呈正相關，與25（OH）D水平呈負相關；logistic迴歸分析顯示2hPG、LDL‐C、CRP和25（O H ）D是CAS的獨立危險因素。【結論】25（O H ）D是CAS的獨立危險因素，其與新診斷T2DM患者CAS髮生髮展密切相關。
【목적】탐토신진단2형당뇨병（T2DM ）환자혈청25‐간유생소D [25（O H ）D ]여경동맥죽양경화적관계。【결과】의거경동맥내막중층후도（CIM T ），장118례신진단T2DM 환자분위비경동맥죽양경화（NCAS ）조화경동맥죽양경화（CAS）조。비교량조환자25（OH）D이급기타생화지표적차이，병사용logistic회귀분석신진단T2DM환자CAS발생적위험인소。【결과】CAS조찬후2 h혈당（2hPG）、당화혈홍단백（HbA1c）、저밀도지단백담고순（LDL‐C）、C반응단백（CRP）수평균현저고우NCAS조，이기25（OH）D수평저우NCAS조，차이균유통계학의의（균 P ＜0．05）；상관분석현시CIMT 여년령、2hPG、HbA1c、LDL‐C、CRP정정상관，여25（OH）D수평정부상관；logistic회귀분석현시2hPG、LDL‐C、CRP화25（O H ）D시CAS적독립위험인소。【결론】25（O H ）D시CAS적독립위험인소，기여신진단T2DM환자CAS발생발전밀절상관。
[Objective] To explore the relationship between serum 25‐hydroxy vitamin D and carotid athero‐sclerosis in newly diagnosed cases of type 2 diabetes mellitus (T2DM ) .[Methods] According to carotid intima media thickness (CIMT) ,118 patients with newly diagnosed T2DM were divided into non‐carotid atherosclerosis (NCAS) and carotid atherosclerosis (CAS) groups .Two groups were compared in serum 25‐hydroxy vitamin D and clinical characteristics to determine the risk factors of carotid atherosclerosis by logistic regression .[Results]As compared with NCAS group ,the levels of 2h postprandial glucose (PPG) ,HbA1c ,low‐density lipoprotein‐cholesterol (LDL‐C) and C‐reactive protein (CRP) were significantly higher in CAS group .And the level of 25‐hydroxy vitamin D was lower in CAS group .According to Pearson's correlation analysis ,CIMT was positively cor‐related with PPG ,HbA1c ,LDL‐C and CRP and negatively with 25‐hydroxy vitamin D .Logistic regression analy‐sis showed that PPG ,LDL‐C ,CRP ,HOMA‐IR and 25‐hydroxy vitamin D were the risk factors of carotid athero‐sclerosis .[Conclusion] Low serum 25‐hydroxy vitamin D is strongly associated with the development of athero‐sclerosis in patients with T2DM .
