CAJ | 학술논문

目的：观察分析噻托溴铵联合沙美特罗替卡松治疗慢性阻塞性肺疾病合并肺动脉高压的疗效。方法将我院2013年8月～2013年12月收治的慢性阻塞性肺疾病合并肺动脉高压患者共计120例，将其随机均分为三个组，A、B、C各40例，A组患者给予噻托溴铵治疗，B组患者给予沙美特罗替卡松治疗，C组患者给予噻托溴铵联合沙美特罗替卡松治疗。治疗三个月后，观察分析比较其肺功能、6min步行距离和呼吸困难评分。结果治疗三个月后，A组和B组肺功能、6min步行距离和呼吸困难评分比较无统计学差异(P>0.05)；C组肺功能、6min步行距离和呼吸困难评分与A组和B组比较有统计学差异（P<0.05），显示C组治疗效果优于与A组与B组。结论我院的临床实践说明噻托溴铵联合沙美特罗替卡松治疗慢性阻塞性肺疾病合并肺动脉高压的疗效要优于单纯使用噻托溴铵或者沙美特罗替卡松的疗效，此法值得临床推广。
목적：관찰분석새탁추안연합사미특라체잡송치료만성조새성폐질병합병폐동맥고압적료효。방법장아원2013년8월～2013년12월수치적만성조새성폐질병합병폐동맥고압환자공계120례，장기수궤균분위삼개조，A、B、C각40례，A조환자급여새탁추안치료，B조환자급여사미특라체잡송치료，C조환자급여새탁추안연합사미특라체잡송치료。치료삼개월후，관찰분석비교기폐공능、6min보행거리화호흡곤난평분。결과치료삼개월후，A조화B조폐공능、6min보행거리화호흡곤난평분비교무통계학차이(P>0.05)；C조폐공능、6min보행거리화호흡곤난평분여A조화B조비교유통계학차이（P<0.05），현시C조치료효과우우여A조여B조。결론아원적림상실천설명새탁추안연합사미특라체잡송치료만성조새성폐질병합병폐동맥고압적료효요우우단순사용새탁추안혹자사미특라체잡송적료효，차법치득림상추엄。
Objecti v e To observe and analyze the therapy of chronic obstructive pulmonary disease with pulmonary hypertension by tiotropium combined with salmeterol and fluticasone propionate. Methods Patients who were diagnosed as chronic obstructive pulmonary disease with pulmonary hy-pertension in our hospital from2013.8~2013.12 were 120 cases, divided patients randomly into three groups, group A, group B, group C,40 cases in every group.Group A get therapy by tiotropi-um, group B were treated by salmeterol fluticasone propionate therapy, group C were treated by tiotropium combined with salmeterol and fluticasone propionate. After three months of treatment, compare their lung function, 6min walking distance and dyspnea score with each other. Results Af-ter three months of treatment, group A and group B showed no statistically significant difference a-mong lung function, 6min walking distance and dyspnea score (P>0.05); Lung function, 6min walk-ing distance and dyspnea score of group C has a significant differences comparing with group A and group B (P<0.05), the treatment showed that group C has a better result than group A and group B. Conclusions The hospital's clinical practice shows that the results of the therapy of chronic obstructive pulmonary disease with pulmonary hypertension by tiotropium combined with salmeterol and fluticasone propionateis superior to simple use of the efficacy of tiotropium or sal-meterol and fluticasone propionate .It is worthy of promotion in clinic.