CAJ | 학술논문

【目的】探讨引发冠状动脉重度狭窄的相关危险因素。【方法】选取笔者所在医院2011年4月至2014年4月收治的冠状动脉狭窄患者113例和体检健康者50例。将其分为三组，A组为体检健康者50例， B组为轻中度冠状动脉狭窄者61例，C组为重度冠状动脉狭窄者52例。观察各组腹型肥胖比例、高血压比例、体质量指数（BMI）、血尿酸（BUA）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL‐C）、低密度脂蛋白胆固醇（LDL‐C）、脂联素、胰岛素抵抗指数（HOMA‐IR）、心率（HR）等指标，进行组间比较。【结果】C组、B组 HOMA‐IR、BMI、HR、高血压比例、腹型肥胖比例、TC、TG、LDL‐C、BUA均高于A组，差异有统计学意义（ P ＜0．05）；C组、B组HDL‐C、脂联素均低于A组，差异有统计学意义（ P ＜0．05）；C组 HOM A‐IR、BMI、HR、高血压比例、腹型肥胖比例、TC、TG、LDL‐C、BUA均高于B组，差异有统计学意义（ P ＜0．05）；C组HDL‐C、脂联素均低于B组，差异有统计学意义（ P ＜0．05）。【结论】冠状动脉重度狭窄患者伴有糖脂代谢紊乱及血尿酸及脂联素异常，高血尿酸有显著影响其并发严重冠状动脉狭窄的可能性。
【목적】탐토인발관상동맥중도협착적상관위험인소。【방법】선취필자소재의원2011년4월지2014년4월수치적관상동맥협착환자113례화체검건강자50례。장기분위삼조，A조위체검건강자50례， B조위경중도관상동맥협착자61례，C조위중도관상동맥협착자52례。관찰각조복형비반비례、고혈압비례、체질량지수（BMI）、혈뇨산（BUA）、총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL‐C）、저밀도지단백담고순（LDL‐C）、지련소、이도소저항지수（HOMA‐IR）、심솔（HR）등지표，진행조간비교。【결과】C조、B조 HOMA‐IR、BMI、HR、고혈압비례、복형비반비례、TC、TG、LDL‐C、BUA균고우A조，차이유통계학의의（ P ＜0．05）；C조、B조HDL‐C、지련소균저우A조，차이유통계학의의（ P ＜0．05）；C조 HOM A‐IR、BMI、HR、고혈압비례、복형비반비례、TC、TG、LDL‐C、BUA균고우B조，차이유통계학의의（ P ＜0．05）；C조HDL‐C、지련소균저우B조，차이유통계학의의（ P ＜0．05）。【결론】관상동맥중도협착환자반유당지대사문란급혈뇨산급지련소이상，고혈뇨산유현저영향기병발엄중관상동맥협착적가능성。
[Objective] To explore the risk factors for severe coronary artery stenosis .[Methods] A total of 113 cases of coronary heart disease were recruited along with 50 healthy subjects (group A ) .And mild/moderate stenosis ( n=61 ,group B) and severe stenosis ( n=52 ,group C) were assigned .The proportion of abdominal obesity ,hypertension ,proportion of body mass index (BMI) ,blood uric acid (BUA) ,total choles‐terol (TC) ,triglyceride (TG) ,high density lipoprotein cholesterol (HDL‐C) ,low density lipoprotein choles‐terol (LDL‐C) ,adiponectin ,insulin resistance index (calculated HOMA‐IR) and heart rate (HR) indices were compared .[Results] In groups C and B ,HOMI‐IR ,BMI ,HR ,proportion of abdominal obesity ,hyperten‐sion ,proportion ,TC ,TG ,LDL‐C and BUA were higher than those in group A .And the differences were statistically significant ( P<0 .05) .HDL‐C and adiponectin were lower in groups C and B than those in group A .And the differences were statistically significant ( P<0 .05) .HOMA‐IR BMI ,HR ,proportion of abdom‐inal obesity ,hypertension ,proportion ,TC ,TG ,LDL‐C ,and BUA were higher in group C than those in group B .And the differences were statistically significant ( P<0 .05) .HDL‐C and adiponectin were lower in group C than that those in group B .And the differences were statistically significant ( P <0 .05) .[Conclu‐sion] In patients of coronary artery stenosis with glucose and lipid metabolic disorder and blood uric acid and serum adiponectin abnormalities ,high blood uric acid significantly affects the possibility of severe coronary ar‐tery stenosis .