医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2015年
3期
499-500,504
,共3页
李岩%曲亚兰%李丹阳%薛晴
李巖%麯亞蘭%李丹暘%薛晴
리암%곡아란%리단양%설청
平滑肌瘤/外科学%子宫肿瘤/外科学%肿瘤复发 ,局部/预防和控制%米非司酮/治疗应用
平滑肌瘤/外科學%子宮腫瘤/外科學%腫瘤複髮 ,跼部/預防和控製%米非司酮/治療應用
평활기류/외과학%자궁종류/외과학%종류복발 ,국부/예방화공제%미비사동/치료응용
Leiomyoma/SU%Uterine Neoplasms/SU%Neoplasm Recurrence,Local/PC%Mife-pristone/TU
【目的】探讨米非司酮预防子宫肌瘤患者术后复发的疗效。【方法】选择子宫肌瘤患者136例,按照术后是否用药分为两组,每组68例,观察组术后每晚服用米非司酮12.5mg,1次/天,连续服用1个月为一个疗程,共3个疗程;对照组术后不给予米非司酮或其他激素类药物治疗。比较两组术后1、12个月时血清卵泡刺激素(FSH)、雌二醇(E2)及孕酮水平和术后12个月复发率,记录观察组患者服药期间的不良反应。【结果】观察组术后12个月内的总复发率为2.9%(2/68),显著低于对照组14.7%(10/68),差异有统计学意义(P<0.05);观察组术后1个月FSH、E2及孕酮激素水平显著低于对照组(P<0.05),术后12个月3项激素水平比较无显著性差异(P>0.05),观察组服药期间仅部分患者出现轻微不良反应,在停药后均恢复正常。【结论】米非司酮可降低子宫肌瘤术后的复发率,且无明显不良反应。
【目的】探討米非司酮預防子宮肌瘤患者術後複髮的療效。【方法】選擇子宮肌瘤患者136例,按照術後是否用藥分為兩組,每組68例,觀察組術後每晚服用米非司酮12.5mg,1次/天,連續服用1箇月為一箇療程,共3箇療程;對照組術後不給予米非司酮或其他激素類藥物治療。比較兩組術後1、12箇月時血清卵泡刺激素(FSH)、雌二醇(E2)及孕酮水平和術後12箇月複髮率,記錄觀察組患者服藥期間的不良反應。【結果】觀察組術後12箇月內的總複髮率為2.9%(2/68),顯著低于對照組14.7%(10/68),差異有統計學意義(P<0.05);觀察組術後1箇月FSH、E2及孕酮激素水平顯著低于對照組(P<0.05),術後12箇月3項激素水平比較無顯著性差異(P>0.05),觀察組服藥期間僅部分患者齣現輕微不良反應,在停藥後均恢複正常。【結論】米非司酮可降低子宮肌瘤術後的複髮率,且無明顯不良反應。
【목적】탐토미비사동예방자궁기류환자술후복발적료효。【방법】선택자궁기류환자136례,안조술후시부용약분위량조,매조68례,관찰조술후매만복용미비사동12.5mg,1차/천,련속복용1개월위일개료정,공3개료정;대조조술후불급여미비사동혹기타격소류약물치료。비교량조술후1、12개월시혈청란포자격소(FSH)、자이순(E2)급잉동수평화술후12개월복발솔,기록관찰조환자복약기간적불량반응。【결과】관찰조술후12개월내적총복발솔위2.9%(2/68),현저저우대조조14.7%(10/68),차이유통계학의의(P<0.05);관찰조술후1개월FSH、E2급잉동격소수평현저저우대조조(P<0.05),술후12개월3항격소수평비교무현저성차이(P>0.05),관찰조복약기간부부분환자출현경미불량반응,재정약후균회복정상。【결론】미비사동가강저자궁기류술후적복발솔,차무명현불량반응。
[Objective] To explore the recurrence‐preventing efficacies of mifepristone after myomectomy .[Methods] A total of 136 patients with myoma of uterus were recruited and divided randomly into observation and control groups according to whether or not there was an addition of postoperative medication ( n = 68 each) .The control group underwent hysteromyoma resection alone .And the observation group received 3 postoperative one‐month courses of mifepristone per night 12 .5 mg .At 3 and 6 months post‐operation ,the se‐rum levels of hemoglobin (Hb) ,follicle‐stimulating hormone (FSH) ,estradiol (E2 ) and progesterone were compared for two groups .And recurrence rates and adverse reactions were recorded .[Results] The overall 12‐month recurrence rate was significantly lower in observation group than that in control group (2 .9% vs 14 .7% ) .And the difference had statistical significance ( P < 0 .05) .As compared with control group ,the levels of FSH ,E2 and progesterone were significantly lower in observation group at 1 month ( P < 0 .05) . And the above three hormones showed no significant differences at 12 months ( P >0 .05) .During medica‐tion ,mild adverse reactions occurred in some patients and recovered after drug withdrawal .[Conclusion]Mifepristone can reduce and prevent a recurrence of uterine fibroids after myomectomy .