医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2015年
3期
505-507
,共3页
睡眠呼吸暂停 ,阻塞性/并发症%高血压/并发症%内皮缩血管肽类/血液%一氧化氮/生物合成%老年人
睡眠呼吸暫停 ,阻塞性/併髮癥%高血壓/併髮癥%內皮縮血管肽類/血液%一氧化氮/生物閤成%老年人
수면호흡잠정 ,조새성/병발증%고혈압/병발증%내피축혈관태류/혈액%일양화담/생물합성%노년인
Sleep Apnea,Obstructive/CO%Hypertension/CO%Endothelins/BL%Nitric Oxide/BI%Aged
【目的】探讨老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压患者血浆内皮素(ET‐1)及内源性一氧化氮(NO)的表达及意义。【方法】选取老年OSAHS合并高血压患者60例(A组)、单纯老年OS‐AHS患者60例(B组)及正常健康体检者60例(C组),采用ELISA法测定ET‐1,硝酸还原酶法测定NO ,多导睡眠仪监测睡眠呼吸指标,包括呼吸暂停低通气指数(AHI)、微觉醒指数(MAI)、平均动脉血氧饱和度(MSaO2)、最低动脉血氧饱和度(LSaO2)、呼吸障碍最长时间,分析ET‐1、NO与睡眠呼吸指标的相关性。【结果】A组与B组ET‐1、ET/NO均显著高于C组( P<0.05),NO均低于C组;A组ET‐1、ET/NO显著高于B组( P <0.05), NO低于B组( P<0.05);A组AHI、MAI、呼吸障碍最长时间均显著高于 B组( P<0.05),LSaO2、MSaO2指标均低于B组( P<0.05)。在A组中,血浆ET‐1水平与AHI呈正相关( r=0.526,P<0.05),与LSaO2、MSaO2呈负相关( r=-0.275,r =-0.192,P <0.05);血浆NO水平与AHI、MSaO2呈负相关( r =-0.484,r =-0.536,P<0.05),与LSaO2呈正相关( r=0.589,P<0.05)。【结论】老年OSAHS合并高血压患者血浆ET‐1及NO水平异常,内皮功能损伤可能参与了老年 OSAHS合并高血压病变过程。
【目的】探討老年阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)閤併高血壓患者血漿內皮素(ET‐1)及內源性一氧化氮(NO)的錶達及意義。【方法】選取老年OSAHS閤併高血壓患者60例(A組)、單純老年OS‐AHS患者60例(B組)及正常健康體檢者60例(C組),採用ELISA法測定ET‐1,硝痠還原酶法測定NO ,多導睡眠儀鑑測睡眠呼吸指標,包括呼吸暫停低通氣指數(AHI)、微覺醒指數(MAI)、平均動脈血氧飽和度(MSaO2)、最低動脈血氧飽和度(LSaO2)、呼吸障礙最長時間,分析ET‐1、NO與睡眠呼吸指標的相關性。【結果】A組與B組ET‐1、ET/NO均顯著高于C組( P<0.05),NO均低于C組;A組ET‐1、ET/NO顯著高于B組( P <0.05), NO低于B組( P<0.05);A組AHI、MAI、呼吸障礙最長時間均顯著高于 B組( P<0.05),LSaO2、MSaO2指標均低于B組( P<0.05)。在A組中,血漿ET‐1水平與AHI呈正相關( r=0.526,P<0.05),與LSaO2、MSaO2呈負相關( r=-0.275,r =-0.192,P <0.05);血漿NO水平與AHI、MSaO2呈負相關( r =-0.484,r =-0.536,P<0.05),與LSaO2呈正相關( r=0.589,P<0.05)。【結論】老年OSAHS閤併高血壓患者血漿ET‐1及NO水平異常,內皮功能損傷可能參與瞭老年 OSAHS閤併高血壓病變過程。
【목적】탐토노년조새성수면호흡잠정저통기종합정(OSAHS)합병고혈압환자혈장내피소(ET‐1)급내원성일양화담(NO)적표체급의의。【방법】선취노년OSAHS합병고혈압환자60례(A조)、단순노년OS‐AHS환자60례(B조)급정상건강체검자60례(C조),채용ELISA법측정ET‐1,초산환원매법측정NO ,다도수면의감측수면호흡지표,포괄호흡잠정저통기지수(AHI)、미각성지수(MAI)、평균동맥혈양포화도(MSaO2)、최저동맥혈양포화도(LSaO2)、호흡장애최장시간,분석ET‐1、NO여수면호흡지표적상관성。【결과】A조여B조ET‐1、ET/NO균현저고우C조( P<0.05),NO균저우C조;A조ET‐1、ET/NO현저고우B조( P <0.05), NO저우B조( P<0.05);A조AHI、MAI、호흡장애최장시간균현저고우 B조( P<0.05),LSaO2、MSaO2지표균저우B조( P<0.05)。재A조중,혈장ET‐1수평여AHI정정상관( r=0.526,P<0.05),여LSaO2、MSaO2정부상관( r=-0.275,r =-0.192,P <0.05);혈장NO수평여AHI、MSaO2정부상관( r =-0.484,r =-0.536,P<0.05),여LSaO2정정상관( r=0.589,P<0.05)。【결론】노년OSAHS합병고혈압환자혈장ET‐1급NO수평이상,내피공능손상가능삼여료노년 OSAHS합병고혈압병변과정。
[Objective] To explore the expression and significance of endothelin‐1 (ET‐1) and endogenous nitric oxide (NO) in senile hypertensive patients with obstructive sleep apnea hypopnea syndrome (OSAHS) .[Methods] A total of 60 senile hypertensive OSAHS patients were recruited from May 2012 to August 2014 . And 60 simple OSAHS elders and 60 healthy subjects were selected as controls .ET‐1 was measured by en‐zyme‐linked immunosorbent assay (ELISA) and NO by nitrate reduction enzymatic method .And such sleep apnea monitoring indicators as apnea‐hypopnea index (AHI) ,arousal index (MAI) ,average oxygen saturation (MSaO2 ) ,lowest oxygen saturation (LSaO2) and longest time of respiratory disorders were determined by polysomnography .The clinical data were recorded and analyzed .[Results] AHI ,MAI and respiratory disor‐der maximum time were significantly higher in OSAHS with hypertension group than those in OSAHS group ( P <0 .05) .Both LSaO2 and MSaO2 were lower in OSAHS group than those in control group ( P <0 .05) . ET‐1 and ET/NO were significantly higher in OSAHS and OSAHS hypertension groups ( P<0 .05) ,NO was lower in control group than that in OSAHS group .ET‐1 and ET/NO were significantly higher in OSAHS with hypertension group than those in OSAHS group ( P<0 .05) .NO was lower in OSAHS group ( P <0 .05) . Plasma ET‐1 level and AHI were positively correlated ( r=0 .526 ,P<0 .05) and LSaO2 and MSaO2 negative‐ly correlated ( r = -0 .275 ,r = -0 .192 ,P<0 .05) .In hypertensive patients with OSAHS ,the plasma level of NO and AHI had negative correlations with MSaO2 ( r = -0 .484 ,r = -0 .536 ,P <0 .05) and a positive correlation with LSaO2 ( r =0 .589 ,P<0 .05) .[Conclusion] The plasma levels of ET‐1 and NO are abnormal in senile OSAHS patients with hypertension .And endothelial dysfunction may be involved in disease process .