中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
2期
117-121
,共5页
杨进华%吴方琴%文强%张文才%王燕鸽%熊欣%舒砚文%程龙献
楊進華%吳方琴%文彊%張文纔%王燕鴿%熊訢%舒硯文%程龍獻
양진화%오방금%문강%장문재%왕연합%웅흔%서연문%정룡헌
冠状动脉疾病%基因多态性%冠状动脉造影
冠狀動脈疾病%基因多態性%冠狀動脈造影
관상동맥질병%기인다태성%관상동맥조영
Coronary artery disease%Gene polymorphism%Coronary arteriography
目的 探讨ST2基因多态性与冠心病患者冠状动脉狭窄程度的相关性. 方法 采用病例对照研究,选取2008-2012年在武汉协和医院就诊的湖北省汉族人群冠心病患者352例,根据临床情况分为心肌梗死(MI)组和非MI组,并根据冠状动脉造影中累及冠状动脉血管病变情况分组.从Hapmap中挑选ST2信号转导通路中单核苷酸多态性(SNPS)位点,采用Sequenom MassArray和Taqman基因分型技术,分析其在心肌梗死人群中基因型和等位基因频率的分布,并研究其与冠心病人群中冠状动脉病变程度的相关性. 结果 共9个SNPS位点符合入选条件.其中ST2的核苷酸多态rs12999364的基因型CC和TT分布频率在冠心病多支病变患者中高于单支病变组(P=0.016),其组合基因型TT+ CT的分布频率在冠心病多支病变患者中低于单支病变人群(P=0.021).经二元回归校正年龄、性别、吸烟和饮酒、高血压、糖尿病、冠心病家族史、体质指数、三酰甘油、总胆固醇等相关危险因素后,rs12999364中的基因型CT(OR=0.47,95%CI:0.285~0.778,P=0.003)和TT+CT(OR=0.555,95%CI:0.347~0.888,P=0.014)是冠心病多支病变的独立保护因素,在MI组中这种保护作用依然独立存在(CT:OR=0.393,95%CI:0.189~0.813,P=0.012;TT+CT:OR=0.453,95%CI:0.228~0.901,P=0.024). 结论 ST2基因多态rs12999364与冠心病患者冠状动脉病变严重程度有关,是冠心病、心肌梗死患者多支病变的保护因素.
目的 探討ST2基因多態性與冠心病患者冠狀動脈狹窄程度的相關性. 方法 採用病例對照研究,選取2008-2012年在武漢協和醫院就診的湖北省漢族人群冠心病患者352例,根據臨床情況分為心肌梗死(MI)組和非MI組,併根據冠狀動脈造影中纍及冠狀動脈血管病變情況分組.從Hapmap中挑選ST2信號轉導通路中單覈苷痠多態性(SNPS)位點,採用Sequenom MassArray和Taqman基因分型技術,分析其在心肌梗死人群中基因型和等位基因頻率的分佈,併研究其與冠心病人群中冠狀動脈病變程度的相關性. 結果 共9箇SNPS位點符閤入選條件.其中ST2的覈苷痠多態rs12999364的基因型CC和TT分佈頻率在冠心病多支病變患者中高于單支病變組(P=0.016),其組閤基因型TT+ CT的分佈頻率在冠心病多支病變患者中低于單支病變人群(P=0.021).經二元迴歸校正年齡、性彆、吸煙和飲酒、高血壓、糖尿病、冠心病傢族史、體質指數、三酰甘油、總膽固醇等相關危險因素後,rs12999364中的基因型CT(OR=0.47,95%CI:0.285~0.778,P=0.003)和TT+CT(OR=0.555,95%CI:0.347~0.888,P=0.014)是冠心病多支病變的獨立保護因素,在MI組中這種保護作用依然獨立存在(CT:OR=0.393,95%CI:0.189~0.813,P=0.012;TT+CT:OR=0.453,95%CI:0.228~0.901,P=0.024). 結論 ST2基因多態rs12999364與冠心病患者冠狀動脈病變嚴重程度有關,是冠心病、心肌梗死患者多支病變的保護因素.
목적 탐토ST2기인다태성여관심병환자관상동맥협착정도적상관성. 방법 채용병례대조연구,선취2008-2012년재무한협화의원취진적호북성한족인군관심병환자352례,근거림상정황분위심기경사(MI)조화비MI조,병근거관상동맥조영중루급관상동맥혈관병변정황분조.종Hapmap중도선ST2신호전도통로중단핵감산다태성(SNPS)위점,채용Sequenom MassArray화Taqman기인분형기술,분석기재심기경사인군중기인형화등위기인빈솔적분포,병연구기여관심병인군중관상동맥병변정도적상관성. 결과 공9개SNPS위점부합입선조건.기중ST2적핵감산다태rs12999364적기인형CC화TT분포빈솔재관심병다지병변환자중고우단지병변조(P=0.016),기조합기인형TT+ CT적분포빈솔재관심병다지병변환자중저우단지병변인군(P=0.021).경이원회귀교정년령、성별、흡연화음주、고혈압、당뇨병、관심병가족사、체질지수、삼선감유、총담고순등상관위험인소후,rs12999364중적기인형CT(OR=0.47,95%CI:0.285~0.778,P=0.003)화TT+CT(OR=0.555,95%CI:0.347~0.888,P=0.014)시관심병다지병변적독립보호인소,재MI조중저충보호작용의연독립존재(CT:OR=0.393,95%CI:0.189~0.813,P=0.012;TT+CT:OR=0.453,95%CI:0.228~0.901,P=0.024). 결론 ST2기인다태rs12999364여관심병환자관상동맥병변엄중정도유관,시관심병、심기경사환자다지병변적보호인소.
Objective To investigate the relationship between ST2 gene polymorphism and the severity of coronary artery stenosis via angiography.Methods With a case-control design,352 Hubei Han Chinese patients with coronary heart disease treated at Wuhan Union Hospital from 2008 to 2012 were enrolled in the study.Participants were divided into two groups,the myocardial infarction group and the non-myocardial infarction group,based on clinical data and coronary artery involvement on angiogram.Single Nucleotide Polymor phisms(SNPs) in the ST2 signal transduction pathways chosen from the Hapmap were subjected to analysis using the Sequenom MassArray system and Taqman probes to determine their genotype and allele frequency distribution in myocardial infarction patients and their association with varying degrees of coronary artery involvement in these patients.Results A total of nine SNPs met the inclusion criteria,of which,the frequency distribution of the genotypes TT and CC of the ST2 SNP rs12999364 was higher in the multivessel lesion group than in the single vessel lesion group (P=0.016),while the distribution frequency of the combined genotype TT+CT was lower in the multivessel lesion group than in the single vessel lesion group (P=0.021).With adjustment for traditional risk factors,including age,gender,smoking,drinking,hypertension,diabetes mellitus,family history of CAD,body mass index,triglyceride and total cholesterol,logistic regression analysis showed that genotypes CT and TT+ CT in rs12999364 were independent protective factors for multivessel lesions not only in CAD (CT:OR=0.471,95%CI =0.285-0.778,P=0.003;TT+CT:OR=0.555,95%CI:0.347-0.888,P=0.014),but also in the myocardial infarction (MI) subgroup (CT:OR=0.393,95%CI:0.189-0.813,P=0.012; TT+CT:OR=0.453,95%CI:0.228-0.901,P=0.024).Conclusions ST2 gene polymorphism rs12999364 is associated with angiographic severity of coronary heart disease and exhibits protective effects for CAD patients and myocardial infarction patients with multivessel lesions.