中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
2期
194-196
,共3页
周蓉%张成%马靖%王广发
週蓉%張成%馬靖%王廣髮
주용%장성%마정%왕엄발
睡眠呼吸暂停综合征%衰老
睡眠呼吸暫停綜閤徵%衰老
수면호흡잠정종합정%쇠로
Sleep apnea syndromes%Aging
目的 研究增龄对大鼠睡眠呼吸暂停的影响. 方法 成年健康雄性清洁级SD大鼠,其中青年组(3月龄)、中年组(12～14月龄)、老年组(18～ 20月龄)每组6只,行手术安放脑电及肌电电极,在体描箱中进行睡眠呼吸监测. 结果 非快速动眼睡眠期(NREM)青、中、老年组自发性睡眠呼吸暂停指数(SPAI)分别为0.41(0.00,1.14)次/h、0.76(0.00,6.28)次/h、2.13(1.44,3.87)次/h,随增龄呈增加趋势(x2 =8.801,P=0.012).青、中、老年组NREM期每次叹息后呼吸暂停的时间依次为(3.51±0.18)s、(3.84±0.57)s、(4.36±0.57)s,各组间比较差异有统计学意义(F=4.729,P=0.026).快速动眼睡眠期(REM) SPAI、每次自发性呼吸暂停持续时间以及NREM期平均每次自发性呼吸暂停持续时间均随增龄有增加趋势,但各组间比较差异均无统计学意义(均P＞0.05). 结论 不同年龄组SD大鼠睡眠呼吸暂停指数、呼吸暂停累计时间、平均每次暂停持续时间随增龄有增加趋势,与人群中的结果相似.
目的 研究增齡對大鼠睡眠呼吸暫停的影響. 方法 成年健康雄性清潔級SD大鼠,其中青年組(3月齡)、中年組(12～14月齡)、老年組(18～ 20月齡)每組6隻,行手術安放腦電及肌電電極,在體描箱中進行睡眠呼吸鑑測. 結果 非快速動眼睡眠期(NREM)青、中、老年組自髮性睡眠呼吸暫停指數(SPAI)分彆為0.41(0.00,1.14)次/h、0.76(0.00,6.28)次/h、2.13(1.44,3.87)次/h,隨增齡呈增加趨勢(x2 =8.801,P=0.012).青、中、老年組NREM期每次歎息後呼吸暫停的時間依次為(3.51±0.18)s、(3.84±0.57)s、(4.36±0.57)s,各組間比較差異有統計學意義(F=4.729,P=0.026).快速動眼睡眠期(REM) SPAI、每次自髮性呼吸暫停持續時間以及NREM期平均每次自髮性呼吸暫停持續時間均隨增齡有增加趨勢,但各組間比較差異均無統計學意義(均P＞0.05). 結論 不同年齡組SD大鼠睡眠呼吸暫停指數、呼吸暫停纍計時間、平均每次暫停持續時間隨增齡有增加趨勢,與人群中的結果相似.
목적 연구증령대대서수면호흡잠정적영향. 방법 성년건강웅성청길급SD대서,기중청년조(3월령)、중년조(12～14월령)、노년조(18～ 20월령)매조6지,행수술안방뇌전급기전전겁,재체묘상중진행수면호흡감측. 결과 비쾌속동안수면기(NREM)청、중、노년조자발성수면호흡잠정지수(SPAI)분별위0.41(0.00,1.14)차/h、0.76(0.00,6.28)차/h、2.13(1.44,3.87)차/h,수증령정증가추세(x2 =8.801,P=0.012).청、중、노년조NREM기매차우식후호흡잠정적시간의차위(3.51±0.18)s、(3.84±0.57)s、(4.36±0.57)s,각조간비교차이유통계학의의(F=4.729,P=0.026).쾌속동안수면기(REM) SPAI、매차자발성호흡잠정지속시간이급NREM기평균매차자발성호흡잠정지속시간균수증령유증가추세,단각조간비교차이균무통계학의의(균P＞0.05). 결론 불동년령조SD대서수면호흡잠정지수、호흡잠정루계시간、평균매차잠정지속시간수증령유증가추세,여인군중적결과상사.
Objective To investigate the effect of aging on the sleep apneas syndrome in Sprague-Dawley (SD) rats.Methods 18 male SD rats in a SPF grade were divided into three groups:young (3-month-old rats,n=6),middle-aged(12-14-month-old rats,n=6) and old group (18-20-month-old rats,n=6).The rats were implanted with EEG and ECG electrodes and underwent sleep monitoring.Results During non-rapid eye movement (NREM),the spontaneous apnea index (SPAI) in young,middle-aged and old groups were increased with aging [0.41 (0.00-1.14)times/h,0.76(0.00-6.28)times/h,2.13(1.44-3.87)times/h respectively,(x2=8.801,P=0.012)].There were significant differences in the average time of post sigh apnea in NREM between the three groups [(3.51±0.18)sec vs.(3.84±0.57)sec vs.(4.36±0.57) sec,F=4.729,P=0.026].SPAI in NREM and the average time of post-sigh apnea in rapid eye movement (REM) as well as NREM showed an increase trend with aging,but there was no significant difference between groups (both P ＞0.05).Conclusions The apnea index,total time of sleep apneas and the average time of postsigh apnea are increased with aging,which is similar to that in human.
