CAJ | 학술논문

近年来药物小分子与DNA相互作用的研究引起广泛关注并取得了重要进展。其中黄酮类化合物在自然界尤其是植物中大量存在，具有广泛的生物学作用，包括抗肿瘤、抗氧化、抗突变、抗炎症、抗菌等活性，且其结构有利于配合物的形成，亦可作为金属离子的良好配体。探讨黄酮类化合物及其金属配合物与核酸相互作用的研究进展，为开发黄酮类抗癌新药提供一些有用信息。
근년래약물소분자여DNA상호작용적연구인기엄범관주병취득료중요진전。기중황동류화합물재자연계우기시식물중대량존재，구유엄범적생물학작용，포괄항종류、항양화、항돌변、항염증、항균등활성，차기결구유리우배합물적형성，역가작위금속리자적량호배체。탐토황동류화합물급기금속배합물여핵산상호작용적연구진전，위개발황동류항암신약제공일사유용신식。
In recent years,the molecular interaction between small molecules and nucleic acids has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of medicine and molecular biology. Flavonoids are polyphenolic compounds which widely distributed in plants and abundanted in some foods. And it can act as metallic chelator due to its peculiar structure. These compounds are characterized by having high biological activities and many pharmacological properties very useful for the treatment of several diseases. This review highlights the flavonoids and their different metal complexes as well as their interactions with DNA which analytical techniques is fluorescence by several research groups. Especially for the application development of new antitumour medicines.