CAJ | 학술논문

目的：研究复方金沙利胆颗粒的利胆、抗炎作用及其急性毒性。方法用大鼠胆总管引流法观察复方金沙利胆颗粒的利胆作用及二甲苯致小鼠耳廓肿胀模型评价药物的抗炎作用，并评价药物的急性毒性，测定小鼠的最大耐受剂量。结果与正常对照组相比，3个剂量组的复方金沙利胆颗粒能显著增加大鼠的胆汁流量，明显改善二甲苯所致小鼠耳肿胀程度。急性毒性实验连续观察14 d，无动物死亡，肉眼观察未见明显毒性反应。复方金沙利胆颗粒小鼠灌胃给药的最大耐受剂量为244.8 g· kg－1（生药）。结论复方金沙利胆颗粒具有显著的利胆、抗炎作用，其急性毒性小，初步证明是安全的。
목적：연구복방금사리담과립적리담、항염작용급기급성독성。방법용대서담총관인류법관찰복방금사리담과립적리담작용급이갑분치소서이곽종창모형평개약물적항염작용，병평개약물적급성독성，측정소서적최대내수제량。결과여정상대조조상비，3개제량조적복방금사리담과립능현저증가대서적담즙류량，명현개선이갑분소치소서이종창정도。급성독성실험련속관찰14 d，무동물사망，육안관찰미견명현독성반응。복방금사리담과립소서관위급약적최대내수제량위244.8 g· kg－1（생약）。결론복방금사리담과립구유현저적리담、항염작용，기급성독성소，초보증명시안전적。
Objective To investigate the cholagogic and anti -infla-mmatory effects and acute toxicity of Jinshalidan Granules.Methods The cholagogic effect of Jinshalidan Granules was observed and deter-mined by common bile duct drainage in mouse .The acute inflammatory models was established by xylene -induced ear edema to research the inflammatory effects of Jinshalidan Granules.The acute toxicity and the maximum tolerated dose in mice were also studied.Results Compared with the normal control group , the bile secretion for the mouse and the degree of swelling of mice ear induced by xylene were significantly improvemed in all the 3 different dosages of Jinshalidan Granules.After 14 days, continuous observation ,no mouse was found dead and no signifi-cant toxicity occurred by naked eyes.The maximum tolerated dose of Compound Jinshalidan Granules is 244.8 g · kg -1 ( crude drug ).Conclusion Compound Jinshalidan Granules have obviously effects on the increased the bile secretion and anti -inflammatory ,it is has very low acute toxicity in mice and preliminary proven to be safe .