CAJ | 학술논문

目的：探讨特发性肺纤维化患者血清IL-13、TGF-β1、IL-8水平。方法选择在我院治疗的肺纤维化患者60例为研究对象，另选择健康志愿者60例为对照组，检测两组患者血清IL-13、TGF-β1、IL-8水平，并测定动脉血气分析及肺功能相关指标。结果肺纤维化组血清IL-13、TGF-β1、IL-8水平显著高于对照组(P<0.01)。TGF-β1、IL-8与FVC占预计值的百分比呈显著负相关(P<0.01)；TGF-β1、IL-13与FEV1占预计值的百分比呈显著负相关(P<0.01)；TGF-β1与PaO2呈显著负相关，TGF-β1、IL-13与P(A-a)O2呈显著正相关(P<0.01)；IL-8与PaO2、SaO2呈显著负相关(P<0.01)。结论特发性肺纤维化患者血清IL-13、TGF-β1、IL-8水平显著升高，并且与患者肺功能具有负相关关系。
목적：탐토특발성폐섬유화환자혈청IL-13、TGF-β1、IL-8수평。방법선택재아원치료적폐섬유화환자60례위연구대상，령선택건강지원자60례위대조조，검측량조환자혈청IL-13、TGF-β1、IL-8수평，병측정동맥혈기분석급폐공능상관지표。결과폐섬유화조혈청IL-13、TGF-β1、IL-8수평현저고우대조조(P<0.01)。TGF-β1、IL-8여FVC점예계치적백분비정현저부상관(P<0.01)；TGF-β1、IL-13여FEV1점예계치적백분비정현저부상관(P<0.01)；TGF-β1여PaO2정현저부상관，TGF-β1、IL-13여P(A-a)O2정현저정상관(P<0.01)；IL-8여PaO2、SaO2정현저부상관(P<0.01)。결론특발성폐섬유화환자혈청IL-13、TGF-β1、IL-8수평현저승고，병차여환자폐공능구유부상관관계。
Objective To discuss serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis and correlation with lung function. Methods A total of 60 cases with idiopathic pulmonary fibrosis were selected as pulmonary fibrosis group, and 60 healthy volunteers were selected as control group. Serum IL-13, TGF-β1, IL-8, arterial blood gas analy-sis and related indicators of lung function were detected. Results Serum IL-13, TGF-β1, IL-8 levels of idiopathic pul-monary fibrosis group were higher than the control group(P<0.01). TGF-β1, IL-8 were significantly negative correlation with FVC predicted percentage (P<0.01); TGF-β1, IL-13 were significantly negative correlation with FEV1 predicted percentage (P<0.01); TGF-β1 and PaO2 was significantly negative correlation, and TGF-β1, IL-8 were significantly positive correlation with P(A-a)O2 (P<0.01);IL-8 was significantly negative correlation with PaO2 and SaO2 (P<0.01). Conclusion Serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis increase significantly, and are nega-tive correlation with lung function.