现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
9期
1255-1258
,共4页
结直肠癌%癌胚抗原%糖类抗原 19 - 9
結直腸癌%癌胚抗原%糖類抗原 19 - 9
결직장암%암배항원%당류항원 19 - 9
colorectal cancer%carcinoembryonic antigen%carbohydrate antigen 19 - 9
目的：探讨结直肠癌血清癌胚抗原（CEA）、糖类抗原19-9（CA19-9）表达水平以及在结直肠癌诊<br> 断、病情评估和预后判断中的作用。方法：本院自2010年6月至2011年6月共收治128例拟诊结直肠癌患者，采用电化学发光法检测患者 CEA、CA19-9水平，并与结直肠镜及病理结果对比，判断 CEA、CA19-9的诊断价值、与临床病理联系以及与预后的关系。结果：128例拟诊结直肠癌的患者中共确诊结直肠癌98例。CEA 诊断的敏感性、特异性、阳性预测值、阴性预测值分别为67.3%、80.0%、90.3%、42.8%。CA19-9诊断的敏感性、特异性、阳性预测值、阴性预测值分别为69.3%、86.7%、93.5%、46.4%。联合检测的敏感性、特异性、阳性预测值、阴性预测值分别为89.8%、96.7%、98.9%、74.3%。联合诊断的敏感性、特异性、阴性预测值显著高于 CEA、CA19-9单独检测（P <0.05）。TNM 不同分期间 CEA、CA19-9水平存在显著差异（P <0.05），低分化结直肠癌 CEA、CA19-9水平显著高于高分化结直肠癌（P <0.05），管状腺癌的 CEA、CA19-9水平显著高于黏液腺癌（P <0.05）。复发转移和死亡病例 CEA、CA19-9水 平 显 著 高 于 生 存病例（P <0.05）。结论：CEA、CA19-9联合诊断有助于提高诊断价值，CEA、CA19-9与临床病理分期、分化程度、病理类型关系密切，且有助于结直肠癌患者的预后判断。
目的：探討結直腸癌血清癌胚抗原（CEA）、糖類抗原19-9（CA19-9）錶達水平以及在結直腸癌診<br> 斷、病情評估和預後判斷中的作用。方法：本院自2010年6月至2011年6月共收治128例擬診結直腸癌患者，採用電化學髮光法檢測患者 CEA、CA19-9水平，併與結直腸鏡及病理結果對比，判斷 CEA、CA19-9的診斷價值、與臨床病理聯繫以及與預後的關繫。結果：128例擬診結直腸癌的患者中共確診結直腸癌98例。CEA 診斷的敏感性、特異性、暘性預測值、陰性預測值分彆為67.3%、80.0%、90.3%、42.8%。CA19-9診斷的敏感性、特異性、暘性預測值、陰性預測值分彆為69.3%、86.7%、93.5%、46.4%。聯閤檢測的敏感性、特異性、暘性預測值、陰性預測值分彆為89.8%、96.7%、98.9%、74.3%。聯閤診斷的敏感性、特異性、陰性預測值顯著高于 CEA、CA19-9單獨檢測（P <0.05）。TNM 不同分期間 CEA、CA19-9水平存在顯著差異（P <0.05），低分化結直腸癌 CEA、CA19-9水平顯著高于高分化結直腸癌（P <0.05），管狀腺癌的 CEA、CA19-9水平顯著高于黏液腺癌（P <0.05）。複髮轉移和死亡病例 CEA、CA19-9水 平 顯 著 高 于 生 存病例（P <0.05）。結論：CEA、CA19-9聯閤診斷有助于提高診斷價值，CEA、CA19-9與臨床病理分期、分化程度、病理類型關繫密切，且有助于結直腸癌患者的預後判斷。
목적：탐토결직장암혈청암배항원（CEA）、당류항원19-9（CA19-9）표체수평이급재결직장암진<br> 단、병정평고화예후판단중적작용。방법：본원자2010년6월지2011년6월공수치128례의진결직장암환자，채용전화학발광법검측환자 CEA、CA19-9수평，병여결직장경급병리결과대비，판단 CEA、CA19-9적진단개치、여림상병리련계이급여예후적관계。결과：128례의진결직장암적환자중공학진결직장암98례。CEA 진단적민감성、특이성、양성예측치、음성예측치분별위67.3%、80.0%、90.3%、42.8%。CA19-9진단적민감성、특이성、양성예측치、음성예측치분별위69.3%、86.7%、93.5%、46.4%。연합검측적민감성、특이성、양성예측치、음성예측치분별위89.8%、96.7%、98.9%、74.3%。연합진단적민감성、특이성、음성예측치현저고우 CEA、CA19-9단독검측（P <0.05）。TNM 불동분기간 CEA、CA19-9수평존재현저차이（P <0.05），저분화결직장암 CEA、CA19-9수평현저고우고분화결직장암（P <0.05），관상선암적 CEA、CA19-9수평현저고우점액선암（P <0.05）。복발전이화사망병례 CEA、CA19-9수 평 현 저 고 우 생 존병례（P <0.05）。결론：CEA、CA19-9연합진단유조우제고진단개치，CEA、CA19-9여림상병리분기、분화정도、병리류형관계밀절，차유조우결직장암환자적예후판단。
Objective:To investigate expression levels and the role of the serum carcinoembryonic antigen (CEA),carbohydrate antigen 19 - 9(CA19 - 9)in diagnosis,evaluation and prognosis of colorectal cancer. Meth-ods:All 128 patients diagnosed of colorectal cancer were treated and electrochemiluminescence was used for detection of CEA,CA19 - 9 level. Results:Of 128 cases,98 cases were finally diagnosed with colorectal cancer;Sensitivity,spe-cificity,positive predictive value,negative predictive value of CEA diagnostic were 67. 3% ,80. 0% ,90. 3% ,42. 8% . Diagnostic sensitivity,specificity,positive predictive value,negative predictive value of CA19 - 9 were 69. 3% , 86. 7% ,93. 5% ,46. 4% . Sensitivity,specificity,positive predictive value,negative predictive value of combined de-tection were 89. 8% ,96. 7% ,98. 9% ,74. 3% . Sensitivity,specificity,negative predictive value of combined detection were significantly higher than CEA,CA19 - 9(P < 0. 05);There was significant difference between different TNM pe-riods in CEA,CA19 - 9 levels(P < 0. 05);CEA,CA19 - 9 levels of poorly differentiated colorectal cancer were sig-nificantly higher than high differentiated colorectal cancer(P < 0. 05);CEA,CA19 - 9 levels of tubular adenocarcino-ma were significantly higher than mucinous adenocarcinoma(P < 0. 05);CEA,CA19 - 9 levels of recurrence and me-tastasis and deaths were significantly higher than the survival patients(P < 0. 05). Conclusion:CEA,CA19 - 9 com-bined detection helps improve diagnostic value,and CEA,CA19 - 9 are closely related with clinical pathological stage,tumor differentiation,histological type.
