CAJ | 학술논문

目的：探讨术中植入氟尿嘧啶植入剂在原发性肝癌切除术临床治疗中的安全性及有效性。方法回顾性分析2010年12月~2012年11月我市弋矶山医院收治的90例原发性肝癌手术治疗患者的临床治疗资料，其中45例患者术中植入氟尿嘧啶植入剂(观察组)，45例患者术中未植入(对照组)，比较两组患者治疗前后血液学指标、不良反应及术后复发情况。结果观察组患者12个月复发、转移率为10.26%，对照组为19.51%(P<0.05)，观察组患者24个月复发、转移率为17.14%，对照组为30.30%(P<0.05)，两组患者均出现不同程度的不良反应，但差异无统计学意义(P>0.05)，两组治疗前后血液学指标变化情况比较，差异无统计学意义(P>0.05)。结论术中植入氟尿嘧啶植入剂可有效降低原发性肝癌患者的术后复发率，提高原发性肝癌的治疗效果，疗效安全、确切，值得临床推广应用。
목적：탐토술중식입불뇨밀정식입제재원발성간암절제술림상치료중적안전성급유효성。방법회고성분석2010년12월~2012년11월아시익기산의원수치적90례원발성간암수술치료환자적림상치료자료，기중45례환자술중식입불뇨밀정식입제(관찰조)，45례환자술중미식입(대조조)，비교량조환자치료전후혈액학지표、불량반응급술후복발정황。결과관찰조환자12개월복발、전이솔위10.26%，대조조위19.51%(P<0.05)，관찰조환자24개월복발、전이솔위17.14%，대조조위30.30%(P<0.05)，량조환자균출현불동정도적불량반응，단차이무통계학의의(P>0.05)，량조치료전후혈액학지표변화정황비교，차이무통계학의의(P>0.05)。결론술중식입불뇨밀정식입제가유효강저원발성간암환자적술후복발솔，제고원발성간암적치료효과，료효안전、학절，치득림상추엄응용。
Objective To explore the safety and efficacy of intraoperative fluorouracil implants for primary hepatocellu-lar carcinoma. Methods Clinical materials of primary hepatocellular carcinoma had been operative in Yijishan hospital from December 2010 to November 2012 were collected and analyzed. They were 90 cases: 45 cases were treated with fluorouracil implants intraoperative(observation group), 45 cases without intraoperative (control group). Hematological in dex before and after treatment, adverse reactions after treatment and recurrence rates were prepared. Results Recur-rence rate in 12 month of observation group was 10.26% and that of control group was 19.51%(P<0.05). Recurrence rate in 24 month of observation group was 17.14%and that of control group was 30.30%(P<0.05). There were no statis-tic difference between observation group and control group in hematological index before and after treatment and ad-verse reactions (P>0.05). Conclusion Intraoperative fluorouracil implants can reduce the recurrence rates after treat-ment and improve clinical efficacy effectively. It is safe and feasible. It is worth for clinical application.