CAJ | 학술논문

黑色素瘤是源于皮肤，粘膜，眼和中枢神经系统色素沉着区域的黑色素细胞的恶性肿瘤，虽然其发病率不高，但恶性程度极高，并且瘤细胞很早就能发生侵袭与转移，从而使患者预后很差。目前黑色素瘤的治疗方式仍以外科手术治疗为主，联合放疗、化疗、中药的综合治疗方案，然而有关黑色素瘤的中医中药治疗方面的研究尚处于起步阶段。最新研究表明，姜科植物属姜黄、郁金、莪术等的活性成分之一姜黄素具有广泛的抗癌、抗炎、抗氧化等药理特性，特别是姜黄素在黑色瘤的预防和治疗中起到不容忽视的作用，姜黄素主要通过抑制黑色素瘤细胞的增殖，促进其凋亡等途径参与黑色素瘤细胞的消亡。本文主要针对姜黄素抗黑色素瘤及其分子机制研究进展作一综述。
흑색소류시원우피부，점막，안화중추신경계통색소침착구역적흑색소세포적악성종류，수연기발병솔불고，단악성정도겁고，병차류세포흔조취능발생침습여전이，종이사환자예후흔차。목전흑색소류적치료방식잉이외과수술치료위주，연합방료、화료、중약적종합치료방안，연이유관흑색소류적중의중약치료방면적연구상처우기보계단。최신연구표명，강과식물속강황、욱금、아술등적활성성분지일강황소구유엄범적항암、항염、항양화등약리특성，특별시강황소재흑색류적예방화치료중기도불용홀시적작용，강황소주요통과억제흑색소류세포적증식，촉진기조망등도경삼여흑색소류세포적소망。본문주요침대강황소항흑색소류급기분자궤제연구진전작일종술。
Melanoma is a kind of malignant tumor that derived from the melanocytes which often located in skin,mu-cous membrane,eye and pigmentation area of the central nervous system. Although the incidence of malignant melano-ma is not high,it is characterized by high malignant degree because of its early invasion and metastasis which lead to patients have poor prognosis. At present,the comprehensive treatment strategy for malignant melanoma including sur-gery,radiotherapy,chemotherapy and Chinese traditional medicine,however,surgical treatment still remains the first choice for early stage patient,however,studies related to Chinese medicine treatment of melanoma is still in its infan-cy. In recent research,they demonstrate that curcumin which is the active ingredient of zingiberaceae plants,turmeric, rhizoma zedoariae,etc,has extensive pharmacological properties of anti - cancer,anti - inflammatory and antioxidant, especially the potential utility in tumor prevention and treatment. Curcumin can inhibit the proliferation and promote the apoptosis of melanoma cells. In this paper,we will review the research advances in molecular mechanism of curcu-min against melanoma.