CAJ | 학술논문

食管鳞癌是我国常见的消化道恶性肿瘤之一，淋巴结转移是食管鳞癌最常见的转移途径，也是影响食管鳞癌预后的重要因素。既往研究已证实，食管鳞癌的淋巴道转移与肿瘤淋巴管生成调节因子的表达有密切关系，其中血管内皮生长因子- C（vascular endothelial growth factor - C，VEGF - C）在恶性肿瘤的淋巴管生成及淋巴结转移中发挥着重要作用。本文就 VEGF - C 与食管鳞癌淋巴管生成的研究进展作一综述，探讨食管鳞癌淋巴管生成的分子机制，尽可能为食管鳞癌的治疗提供新的理论依据。
식관린암시아국상견적소화도악성종류지일，림파결전이시식관린암최상견적전이도경，야시영향식관린암예후적중요인소。기왕연구이증실，식관린암적림파도전이여종류림파관생성조절인자적표체유밀절관계，기중혈관내피생장인자- C（vascular endothelial growth factor - C，VEGF - C）재악성종류적림파관생성급림파결전이중발휘착중요작용。본문취 VEGF - C 여식관린암림파관생성적연구진전작일종술，탐토식관린암림파관생성적분자궤제，진가능위식관린암적치료제공신적이론의거。
Esophageal squamous cell carcinoma(ESCC)is one of the common malignant tumors in digestive tract in China,and lymph node metastasis is the most common route of metastasis in esophageal squamous cell carcinoma,and also the important factor affecting the prognosis of patients suffering from esophageal squamous cell carcinoma. Previ-ous researches have confirmed that lymphatic metastasis in esophageal squamous cell carcinoma has close relationship with the expression of tumorous lymphangiogenesis regulatory factors,and vascular endothelial growth factor - C (VEGF - C)plays an important role in lymphangiogenesis and lymph node metastasis of malignant tumors. We sum-marizes the research progress on VEGF - C and lymphangiogenesis in esophageal squamous cell carcinoma,discusses the molecular mechanism of lymphangiogenesis in esophageal squamous cell carcinoma,providing new theoretical ba-sis for therapy of esophageal squamous cell carcinoma as far as possible.