CAJ | 학술논문

目的：探讨左旋氨氯地平、氨氯地平在高血压中的治疗效果。方法选取2012年5月~2014年1月我院收治的高血压患者共115例，并随机分为对照组(n=57)和观察组(n=58)。对照组给予苯磺酸氨氯地平片治疗，观察组给予苯磺酸左旋氨氯地平片治疗，对比两组的血压变化情况、治疗疗效和不良反应。结果治疗后，对照组、观察组SBP和DBP水平相比，差异无统计学意义(t=0.378，P=0.706；t=0.187，P=0.352)；观察组高血压治疗有效率为84.5%，与对照组80.7%相比，差异无统计学意义(χ2=0.286，P=0.593)；观察组不良反应率为5.2%，显著低于对照组的21.1%(χ2=6.392，P=0.012)。结论左旋氨氯地平、氨氯地平治疗高血压的效果类似，但左旋氨氯地平的不良反应更低，安全性更高。
목적：탐토좌선안록지평、안록지평재고혈압중적치료효과。방법선취2012년5월~2014년1월아원수치적고혈압환자공115례，병수궤분위대조조(n=57)화관찰조(n=58)。대조조급여분광산안록지평편치료，관찰조급여분광산좌선안록지평편치료，대비량조적혈압변화정황、치료료효화불량반응。결과치료후，대조조、관찰조SBP화DBP수평상비，차이무통계학의의(t=0.378，P=0.706；t=0.187，P=0.352)；관찰조고혈압치료유효솔위84.5%，여대조조80.7%상비，차이무통계학의의(χ2=0.286，P=0.593)；관찰조불량반응솔위5.2%，현저저우대조조적21.1%(χ2=6.392，P=0.012)。결론좌선안록지평、안록지평치료고혈압적효과유사，단좌선안록지평적불량반응경저，안전성경고。
Objective To investigate effect of levamlodipine and amlodipine in treatment of hypertension. Methods A total of 115 cases of hypertension from May 2012 to January 2014 in our hospital were collected, and were randomly divided into control group (n=57) and observation group (n=58). The control group was given amlodipine besylate tablets treatment, while the observation group was given levamlodipine besylate tablets treatment. Adverse reaction, the change of blood pressure, the total curative effect of two groups were compared. Results After treatment, SBP and DBP levels of control group and the observation group had no significant difference (t=0.378, P=0.706; t=0.187, P=0.352). The effective rate of observation group was 84.5%, while the control group was 80.7%, and there was no significant dif-ference between two groups (χ2=0.286, P=0.593). The adverse rate of observation group was 5.2%, which was lower than that of control group 21.1%(χ2=6.392, P=0.012). Conclusion Levamlodipine and amlodipine has a similar treatment ef-fect for hypertension, but the levamlodipine has lower adverse reaction and higher security.