中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
8期
53-56
,共4页
非小细胞肺癌%铂类药物%GSTP1%单核苷酸多态性%Meta分析
非小細胞肺癌%鉑類藥物%GSTP1%單覈苷痠多態性%Meta分析
비소세포폐암%박류약물%GSTP1%단핵감산다태성%Meta분석
non-small cell lung cancer%platinum%GSTP1%single nucleotide polymorphism%meta analysis
目的：系统评价中国人群中非小细胞肺癌( NSCLC )患者GSTP1基因多态性与铂类药物化学治疗(简称化疗)敏感性的相关性。方法计算机检索Cochrane Library，PubMed，EMBASE数据库和中国生物医学文献数据库( CBM )、中国学术期刊全文数据库( CNKI )和中文科技期刊全文数据库维普( VIP )、万方等数据库中有关GSTP1基因多态性与铂类药物化疗敏感性的研究，由2名研究者独立筛选提取资料和评价质量，采用RevMan 5.2软件进行Meta分析。结果有6篇文献符合要求，纳入研究，共527例患者。Meta分析结果显示，GSTP1313 GG基因型( GG vs AA，OR为4.80，95%CI为1.57~14.69)和AG基因型( AG vs AA，OR为3.42，95%CI为1.99~5.86)的患者化疗有效率明显高于AA基因型患者，而且变异基因型G携带者（AG+GG基因型）的化疗有效率明显高于野生型AA基因型患者( AG+GG vs AA，OR为2.38，95% CI为1.61~3.53)。结论中国人群中非小细胞肺癌患者的GSTP1基因多态性与铂类药物化疗敏感性相关。
目的：繫統評價中國人群中非小細胞肺癌( NSCLC )患者GSTP1基因多態性與鉑類藥物化學治療(簡稱化療)敏感性的相關性。方法計算機檢索Cochrane Library，PubMed，EMBASE數據庫和中國生物醫學文獻數據庫( CBM )、中國學術期刊全文數據庫( CNKI )和中文科技期刊全文數據庫維普( VIP )、萬方等數據庫中有關GSTP1基因多態性與鉑類藥物化療敏感性的研究，由2名研究者獨立篩選提取資料和評價質量，採用RevMan 5.2軟件進行Meta分析。結果有6篇文獻符閤要求，納入研究，共527例患者。Meta分析結果顯示，GSTP1313 GG基因型( GG vs AA，OR為4.80，95%CI為1.57~14.69)和AG基因型( AG vs AA，OR為3.42，95%CI為1.99~5.86)的患者化療有效率明顯高于AA基因型患者，而且變異基因型G攜帶者（AG+GG基因型）的化療有效率明顯高于野生型AA基因型患者( AG+GG vs AA，OR為2.38，95% CI為1.61~3.53)。結論中國人群中非小細胞肺癌患者的GSTP1基因多態性與鉑類藥物化療敏感性相關。
목적：계통평개중국인군중비소세포폐암( NSCLC )환자GSTP1기인다태성여박류약물화학치료(간칭화료)민감성적상관성。방법계산궤검색Cochrane Library，PubMed，EMBASE수거고화중국생물의학문헌수거고( CBM )、중국학술기간전문수거고( CNKI )화중문과기기간전문수거고유보( VIP )、만방등수거고중유관GSTP1기인다태성여박류약물화료민감성적연구，유2명연구자독립사선제취자료화평개질량，채용RevMan 5.2연건진행Meta분석。결과유6편문헌부합요구，납입연구，공527례환자。Meta분석결과현시，GSTP1313 GG기인형( GG vs AA，OR위4.80，95%CI위1.57~14.69)화AG기인형( AG vs AA，OR위3.42，95%CI위1.99~5.86)적환자화료유효솔명현고우AA기인형환자，이차변이기인형G휴대자（AG+GG기인형）적화료유효솔명현고우야생형AA기인형환자( AG+GG vs AA，OR위2.38，95% CI위1.61~3.53)。결론중국인군중비소세포폐암환자적GSTP1기인다태성여박류약물화료민감성상관。
Objective To systematically evaluate the relationship between GSTP1 gene polymorphisms in Chinese population with non-small cell lung cancer(NSCLC) and the platinum-based chemotherapy sensitivity. Methods The researches on GSTP1 gene polymor-phisms and the platinum-based chemotherapy sensitivity were retrieved from the databases of the Cochrane Library,PubMed,EMBASE, CBM,CNKI,VIP and Wangfang database. Then the extracted data were independently screened and the quality evaluation was performed by 2 researchers. The meta analysis was performed by adopting the RevMan 5. 2 software. Results A total of 6 articles meeting the requirements were included,involving 527 patients. The meta analysis results showed that the chemotherapy effective rate in the patients with genotype GSTP1 313 GG ( GG vs AA:OR,4. 80;95% CI,1. 57-14. 69 ) and genotype AG ( AG vs AA:OR,3. 42;95% CI,1. 99-5. 86 ) was significantly higher than that in the patients with gynotype AA,moreover the chemotherapy effective rate in the carrier of mutant genotype G(genotype AG+GG)was significantly higher than that in the patients with wild genotype AA ( AG+GG vs AA:OR, 2. 38;95% CI,1. 61-3. 53 ) . Conclusion GSTP1 gene polymorphisms is associated with the platinum-based chemotherapy sensitivity in Chinese population with NSCLC.
