CAJ | 학술논문

目的：探讨大补元煎加减热奄包外敷联合西药治疗慢性肾衰竭衰竭期的疗效。方法选取慢性肾衰竭衰竭期患者100例，按随机数字表法平均分为治疗组和对照组，各50例。治疗组患者给予大补元煎加减热奄包外敷联合西药治疗，对照组患者仅使用常规西药治疗。比较两组患者的疗效以及治疗前后血压（BP）、血肌酐（SCr）、血尿素氮（BUN）、血尿酸（UA）、血红蛋白（Hb）、内生肌酐清除率（Ccr）、白蛋白（ALB）及血电解质的变化情况。结果治疗组总有效率为76.00%，明显高于对照组的46.00%（ P＜0.05）；治疗组患者治疗后的血清SCr，BUN，UA，Hb，ALB，24 h尿蛋白和Ccr水平均较治疗前明显改善，且改善程度明显高于对照组（ P＜0.05）；治疗组患者治疗后的血压及血电解质中K+和HCO3－均较治疗前明显改善，且改善程度优于对照组（ P＜0.05）。结论中药热奄包外敷联合西药治疗慢性肾衰竭衰竭期疗效显著，可有效改善临床症状，延缓肾衰竭进展。
목적：탐토대보원전가감열엄포외부연합서약치료만성신쇠갈쇠갈기적료효。방법선취만성신쇠갈쇠갈기환자100례，안수궤수자표법평균분위치료조화대조조，각50례。치료조환자급여대보원전가감열엄포외부연합서약치료，대조조환자부사용상규서약치료。비교량조환자적료효이급치료전후혈압（BP）、혈기항（SCr）、혈뇨소담（BUN）、혈뇨산（UA）、혈홍단백（Hb）、내생기항청제솔（Ccr）、백단백（ALB）급혈전해질적변화정황。결과치료조총유효솔위76.00%，명현고우대조조적46.00%（ P＜0.05）；치료조환자치료후적혈청SCr，BUN，UA，Hb，ALB，24 h뇨단백화Ccr수평균교치료전명현개선，차개선정도명현고우대조조（ P＜0.05）；치료조환자치료후적혈압급혈전해질중K+화HCO3－균교치료전명현개선，차개선정도우우대조조（ P＜0.05）。결론중약열엄포외부연합서약치료만성신쇠갈쇠갈기료효현저，가유효개선림상증상，연완신쇠갈진전。
Objective To investigate the effect of the external application of modified Dabuyuan Decoction Hot Compress Package combined with Western medicine in treating the exhaustion stage of chronic renal failure. Methods Totally 100 patients with the ex-haustion stage of chronic renal failure were divided into the treatment group and the control group with 50 cases in each group accord-ing the random number table method. The treatment group was treated with the external application of modified Dabuyuan Decoction Hot Compress Package combined with Western medicine,while the control group used only the conventional Western medicine. The curative effects,blood pressure(BP),serum creatinine(SCr),blood urea nitrogen (BUN),blood uric acid(UA),hemoglobin(Hb),endogenous creati-nine clearance rate(Ccr) before and after treatment and changes of blood electrolytes were compared between the two groups. Results The total effective rate in the treatment group was 76. 00%,which was significantly higher than 46. 00% in the control group( P <0. 05);the serum SCr,BUN,UA,Hb,ALB,24h-urine protein and Ccr levels after treatment in the treatment group were significantly improved compared with before treatment,moreover,the improvement degree in the treatment group was significantly higher than that in the control group( P < 0. 05);in addition,blood pressure,blood electrolytes of K+ and HCO3- after treatment in the treatment group were significantly improved compared with those before treatment,and the improvement degree was significantly better than that in the control group( P < 0. 05). Conclusion The external application of modified Dabuyuan Decoction Hot Compress Package combined with Western medicine can effectively improve the clinical symptoms and delay the progression of renal failure in the treatment of chronic renal failure.