中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
11期
122-124,131
,共4页
耐甲氧西林金黄色葡萄球菌%女性生殖道%耐药性
耐甲氧西林金黃色葡萄毬菌%女性生殖道%耐藥性
내갑양서림금황색포도구균%녀성생식도%내약성
Methicillin resistant staphylococcus aureus%Female reproductive tract%Resistance
目的：了解女性生殖道金黄色葡萄球菌的临床分离和耐药变迁，为临床合理用药提供依据。方法收集2008年1月~2013年12月临床分离的女性生殖道非重复SAU，经VITEK-60微生物分析系统进行鉴定和药敏试验，数据分析采用WHONET 5.6软件进行。结果共检出SAU 247株，主要来源于门诊(69.2%)，平均年龄(26.3±4.2)岁。甲氧西林耐药金黄色葡萄球菌(methicillin resistant staphylococcus aureus，MRSA)检出率从2008年的13.5%升至2013年的31.9%，呈逐年递增趋势。药敏结果显示SAU对青霉素和红霉素的耐药率较高(>58.7%)，对其他抗生素的耐药率较低(<25.9%)，未发现万古霉素和利奈唑烷耐药菌株。2008年与2013年相比，苯唑西林、左旋氧氟沙星和四环素的耐药率明显增加，差异有统计学意义(P<0.05)。 MRSA与甲氧西林敏感金黄色葡萄球菌(methicillin sensitive staphylococcus aureus，MSSA)相比，对苯唑西林、氨苄西林/舒巴坦、庆大霉素、左旋氧氟沙星、莫西沙星、克林霉素、红霉素和四环素的耐药率均较高(P<0.05)。结论女性生殖道SAU感染和MRSA检出率呈上升趋势，耐药性日趋严重。应加强SAU的培养检测和耐药性变迁监测，指导临床合理用药。
目的：瞭解女性生殖道金黃色葡萄毬菌的臨床分離和耐藥變遷，為臨床閤理用藥提供依據。方法收集2008年1月~2013年12月臨床分離的女性生殖道非重複SAU，經VITEK-60微生物分析繫統進行鑒定和藥敏試驗，數據分析採用WHONET 5.6軟件進行。結果共檢齣SAU 247株，主要來源于門診(69.2%)，平均年齡(26.3±4.2)歲。甲氧西林耐藥金黃色葡萄毬菌(methicillin resistant staphylococcus aureus，MRSA)檢齣率從2008年的13.5%升至2013年的31.9%，呈逐年遞增趨勢。藥敏結果顯示SAU對青黴素和紅黴素的耐藥率較高(>58.7%)，對其他抗生素的耐藥率較低(<25.9%)，未髮現萬古黴素和利奈唑烷耐藥菌株。2008年與2013年相比，苯唑西林、左鏇氧氟沙星和四環素的耐藥率明顯增加，差異有統計學意義(P<0.05)。 MRSA與甲氧西林敏感金黃色葡萄毬菌(methicillin sensitive staphylococcus aureus，MSSA)相比，對苯唑西林、氨芐西林/舒巴坦、慶大黴素、左鏇氧氟沙星、莫西沙星、剋林黴素、紅黴素和四環素的耐藥率均較高(P<0.05)。結論女性生殖道SAU感染和MRSA檢齣率呈上升趨勢，耐藥性日趨嚴重。應加彊SAU的培養檢測和耐藥性變遷鑑測，指導臨床閤理用藥。
목적：료해녀성생식도금황색포도구균적림상분리화내약변천，위림상합리용약제공의거。방법수집2008년1월~2013년12월림상분리적녀성생식도비중복SAU，경VITEK-60미생물분석계통진행감정화약민시험，수거분석채용WHONET 5.6연건진행。결과공검출SAU 247주，주요래원우문진(69.2%)，평균년령(26.3±4.2)세。갑양서림내약금황색포도구균(methicillin resistant staphylococcus aureus，MRSA)검출솔종2008년적13.5%승지2013년적31.9%，정축년체증추세。약민결과현시SAU대청매소화홍매소적내약솔교고(>58.7%)，대기타항생소적내약솔교저(<25.9%)，미발현만고매소화리내서완내약균주。2008년여2013년상비，분서서림、좌선양불사성화사배소적내약솔명현증가，차이유통계학의의(P<0.05)。 MRSA여갑양서림민감금황색포도구균(methicillin sensitive staphylococcus aureus，MSSA)상비，대분서서림、안변서림/서파탄、경대매소、좌선양불사성、막서사성、극림매소、홍매소화사배소적내약솔균교고(P<0.05)。결론녀성생식도SAU감염화MRSA검출솔정상승추세，내약성일추엄중。응가강SAU적배양검측화내약성변천감측，지도림상합리용약。
Objective To investigate the distribution and the change of drug resistance of staphylococcus aureus(SAU)isolated from female genital tract, and provide evidence for rational use of antibiotic. Methods Non-repetitive staphy-lococcus aureus isolates were collected from female genital tract from January 2008 to December 2013. The identifica-tion and susceptibility of the isolates were determined using auto-microbe analyzer. The data were analyzed by WHONET 5.6. Results A total of 247 SAU stains were determined, mainly from the outpatient (69.2%), mean age(26.3±4.2) years old. The rate of Methicillin-resistant Staphylococcus aureus(MRSA) isolates rose from 13.5% in 2008 to 31.9% in 2013, and showed an increasing trend year by year. The results of antibiotic susceptibility test dis-played that the resistance rates of SAU to penicillin and erythromycin were higher than 58.7%,and the resistance rates to others antibiotic were low(<25.9%). No isolate was resistant to linezolid and vancomycin. Resistance rates to oxacillin,levofloxacin, tetracycline had a significant increasing trend from 2008 to 2013(P<0.05). MRSA strains to oxacillin,ampicillin/sulbactam,gentamicin,levofloxacin, moxifloxacin, clindamycin, erythromycin and tetracycline were higher than MSSA (P<0.05). Conclusion The female reproductive tract infection with MRSA had an upward trend, and its resistance became increasingly serious. therefore,we should reinforce the surveillance of this kind of strains for the guide of rational use of antimicrobial agents in clinic.
